Website is intended for physicians



A multicentered study based on retrospective data covered 2012 patients and aimed at ascertaining the eficiency of various methods of treating patients with coronary restenosis after stenting. The average percent of complications after restenosis was about 20% during the period of study (1 1+4 months). The metaregression data analysis showed the positive correlation between the stage of residual stenosis of the stentet segment and the probability of complications. As the residual stenosis decreased at 1%, the frequency of complications diminished at 0,9%. Another factors under analysis did not show any evident influence, although we have registered a tendency towards better outcomes of the recurring operations as the diameter of the vessel increased. The recurring balloon angioplasty in cases of short restenosis and intracoronar radiation in cases of diffused restenotic lesions have proved to be the most effective operations. The indications for implanting the additional stents must be given very carefully, especially in cases of diabetes.



1.     Fischman D.L., Leon M.D., Baim D.S., et al. A randomized comparison of coronary stent placement and balloon angioplasty in treatment of coronary artery disease. N. Engl. J. Med. 1994; 331: 496 - 501.

2.     Serruys P.W, de Jaeger P., Kimeneij E, et al. A comparison of balloon-expandable stent implantation with balloon angioplasty in patients with coronary heart disease. N. Engl]. Med. 1994; 331: 489 - 495.

3.     Di Mario C, Marsico E, Adamian M. et al. New recipes for in-stent restenosis: cut, grate, roast, or sandwich the neointima? Heart. 2000; 84: 471 - 475.

4.     Hoffmann R., Mintz G. S. Coronary in-stent restenosis-predictors, treatment and prevention. Eur. Heart J. 2000; 21: 1739- 1749.

5.     Leon M.B., Tierstein P.S., Moses J.W et al. Localized intracoronary gamma-radiation therapy to inhibit the occurrence of restenosis after stenting. N. Egl. J. Med. 2001; 344: 250-256.

6.     Waksman R., White R.L., Chan R.C., et al. Intracoronary gamma-radiation therapy after angioplasty inhibits reccurence in patients with in-stent restenosis. Circulation. 2000; 101: 2165 - 2171.

7.     Sousa J. E., Costa M.A., Abizaid A., et al. Lack of neoitimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation. 2001; 10: 192 - 195.

8.     Kuntz R.E., Gibson СМ., Nobuyoshi M., et al. Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy. J. Am. Coll. Cardiology. 1993; 21: 15 - 25. (АНГИОЛОГИЯ.ру) - портал о диагностике и лечении заболеваний сосудистой системы