Website is intended for physicians




Inflammatory breast cancer (BC) is a locally-spread unresectable primary diffuse form of tumor, occurring in 1- 6% of patients with breast cancer, and is one of the most malignant forms of cancer with a poor prognosis and a low survival rate.

The article describes the clinical case of successful experience in the application of repeated chemoembolization and one cycle of radical radiation therapy in patient with metastatic breast cancer (inflammatory form), resistant to conduct systemic chemotherapy (possibility to transfer tumor into operable condition).

Patient underwent three cycles of chemoembolization into right internal thoracic artery, followed by radical radiotherapy The combination of these techniques allowed to reach a complete response to treatment and subsequently perform a radical mastectomy. Postoperative follow-up period is 85 months of remission without specific therapy.



1.     Dawood S., Lei X., Dent R. et al. Survival of women inflammatory breast cancer: a lage population-based study. Ann. Oncol. 2014; 25(6): 1143-1151.

2.     Wilke D., Colwell B., Dewar R. Inflammatory breast carcinoma: comparison of survival of those diagnosed clinically, pathologically, or with both features. Am Surg. 1998; 64(5):428-431.

3.     Henderson M.A., Mc Bride C.M. Secondary inflammatory breast cancer: treatment options. South Med J. 1988; 81(12):1512-15177.

4.     Liauw S.L., Benda R.K., Morris C.G, et al, Inflammatory breast carcinoma: Outcomes with trimodality therapy for nonmetastatic disease. Cancer. 200; 100(5): 920-928.

5.     Masljukova E.A., Odincova S.V., Korytova L.I., Polikarpov A.A., Zhabina R.M. Vnutriarterial'naja himioterapija i luchevaja terapija v kombinirovannom lechenii bol'nyh rakom molochnoj zhelezy[Intra-arterial chemotherapy and radiation therapy in combined treatment of patients with breast cancer.]. Vestnik novyh medicinskih tehnologij. Jelektronnoe izdanie. 2015:4:2-10 [In Rus].

6.     Belka C. Biological Basis of Combined Radio and Chemotherapy. Multimodal Concepts for Integration of Cytotoxic Drugs. Ed. Brady L.W. et al., Springer, Heidelberg. 2006;3-17.

7.     Harada H. Combinations of Antimetabolites and Ionizing Radiation. Multimodal Concepts for Integration of Cytotoxic Drugs. Ed. Brady L.W. et al. Springer, Heidelberg. 2006;19-34.

8.     Perez C.A., Fields J.N., Fracasso PM., et. al, Management of locally advanced carcinoma of the breast. Inflammatory carcinoma. Cancer. 1994;74 (Supll 1): 466-76.

9.     Chhikvadze T.B. Mesto luchevogo, lekarstvennogo i hirurgicheskogo jetapov v kompleksnom lechenii otechnyh form raka molochnoj zhelezy [Role of beam, medicinal and surgical stages in complex treatment of inflammatory forms of breast cancer]: dis. kand. med. nauk: M., 2008; 82 [In Russ].

10.   Cristofanilli M., Valero V., Buzdar A.U. et al. Inflammatory breast cancer (IBC): patterns of recurrence and micrometastatic homing. Breast Cancer Res. Treat. 2006;100(Suppl 1):155.

11.   Fisher B, Brown A, Mamounas E. et. al. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol. 1997; 15(7): 2483-2493.

12.  Granov A.M., Davydov M.I. Intervencionnaja radiologija v onkologii (puti razvitija i tehnologii) [Interventional radiology in oncology (path of development and technology)]. Izdanie vtoroe, dopolnennoe. Spb: Foliant, 2013;560 [In Russ]. (АНГИОЛОГИЯ.ру) - портал о диагностике и лечении заболеваний сосудистой системы