Production of medicinal product radiopharmaceutical 18F-fluorodeoxyglucose

DOI: https://doi.org/10.25512/DIR.2018.12.1.03

For quoting:
Nevzorov D.I., Skripachev I.A., Dolgushin M.B., Odzharova A.A., Eremin N.V. "Production of medicinal product radiopharmaceutical 18F-fluorodeoxyglucose". Journal Diagnostic & interventional radiology. 2018; 12(1); 34-42.

authors:

Nevzorov D.I.

Skripachev I.A.

Dolgushin M.B.

Odzharova A.A.

Eremin N.V.

keywords:

18F-FDG

18F-fluorodeoxyglucose

synthesis

radiopharmaceutical

RPh

positron emission tomography

Abstract:

In the article considers modern commercial method of production is demanded used in oncology medical product radiopharmaceutical ¹⁸F-fluorodeoxyglucose (2-fluoro,¹⁸F-2-deoxy-D-glucose, ¹⁸F-FDG), are presented the process steps and operation of synthesis, quality control procedures, briefly described the requirements for packaging and labeling of radiopharmaceutical.

References

1. Kam Leung. [¹⁸F]Fluoro-2-deoxy-2-D-glucose in Molecular Imaging and Contrast Agent Database (MICAD). National Center for Biotechnology Information, NLM, NIH, Bethesda, MD. 2005.

2. Min-Fu Yang, Diwakar Jain, Zuo-Xiang He. ¹⁸F-FDG Cardiac Studies for Identifying Ischemic Memory. Curr Cardiovasc Imaging Rep. 2012; Dec, 5:383-389.

3. Ghesani M., Depuey E. G., Rozanski A. Role of F-¹⁸ FDG positron emission tomography (PET) in the assessment of myocardial viability. Echocardiography. 2005 Feb; 22(2): 165-77.

4. Nose H., Otsuka H., Otomi Y et al. Evaluation of normal physiologic left ventricular myocardial ¹⁸F-FDG uptake at fasting state. European Congress of Radiology. 2012. Vienna, Austria. URL: http://posterng.netkey.at/esr/ viewing/index.php?module=viewing_poster&doi=10.1594 /ecr2012/C-1192 2012.

5. Dong Soo Lee, Sang Kun Lee, Myung Chul Lee. Functional Neuroimaging in Epilepsy: FDG PET and Ictal SPECT. Korean Med Sci. 2001;16: 689-96.

6. Teune L. K., Bartels A. L., Leenders K. L. FDG-PET Imaging in Neurodegenerative Brain Diseases // Functional Brain Mapping and the Endeavor to Understand the Working Brain edited by Francesco Signorelli and Domenico Chirchiglia, 2013.

7. Sanchez-Catasis C. A., Vallez, Garcha D., Le Riverend Morales E., Galvizu Sбnchez R. Traumatic Brain Injury: Nuclear Medicine Neuroimaging .PET and SPECT in Neurology. 2014; 923-946.

8. Masangkay N., Basu S., Moghbel M. et al. Brain ¹⁸F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings. Nucl Med Commun. 2014 Oct; 35 (10): 1038-46.

9. Statistika zlokachestvennyh novoobrazovanij v Rossii i stranah SNG v 2012 g. Pod redakciej M.I. Davydova, E.M. Aksel'. [Statistics of malignant neoplasms in Russia and CIS countries in 2012. Edited by M.I. Davydova, E.M. Axel.] Moskva, 2014. - 226 s [In Russ].

10. Jones S. C., Alavi A., Christman D. et al. The radiation dosimetry of 2 [F-¹⁸]fluoro-2-deoxy-D-glucose in man. J Nucl Med. 1982; 23, 613-617.

11. Kuwabara H., Gjedde A. Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate. J Nucl Med. 1991 Apr; 32(4): 692-8.

12. Data are from International Commission on Radiological Protection. Radiation Dose to Patients from Radiopharmaceuticals. St. Louis, MO. Elsevier; 2000:49. ICRP publication 80.

13. Ido T., Wan C. N., Fowler J. S. Fluorination with F2: convenient synthesis of 2-deoxy-2-fluoro-d-glucose. J Org Chem. 1977; 42: 2341-2.

14. Hamacher K., Coenen H. H., Stacklin G. Efficient stereospecific synthesis of no-carrier-added 2-[¹⁸F]- fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986; 27: 235-8.

15. Toorongian S. A., Mulholland G. K., Jewett D. M. et al. Routine production of 2-deoxy-2-[¹⁸F]fluoro-D- glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Int J Rad Appl Instrum B. 1990; 17 (3): 273-9.

16 Normy radiacionnoj bezopasnosti (NRB-99/2009). [Norms of radiation safety (NRB-99/2009).] SP 2.6.1.2523-09.[In Russ].

17. Osnovnye sanitarnye pravila obespecheniya radiacionnoj bezopasnosti (OSPORB-99/2010). [Basic sanitary rules for ensuring radiation safety (0SP0RB-99/2010)]. SP 2.6.12612-10 [In Russ].

18. SanPiN 2.6.1.3288-15 «Gigienicheskie trebovaniya po obespecheniyu radiacionnoj bezopasnosti pri podgotovke i provedenii pozitronnoj ehmissionnoj tomografii». [Hygienic requirements for ensuring radiation safety in the preparation and conduct of positron emission tomography.] [ In Russ].

19. N.A. Gomzina, D.A. Vasil’ev, R.N. Krasikova. Optimization of Automated Synthesis of 2-[¹⁸F]Fluoro- 2-deoxy-D-glucose Involving Base Hydrolysis. Radiochemistry. 2002; 44 (4): 403-409.

20. Gopal B. Saha. Basics of PET Imaging: Physics, Chemistry and Regulations. - 3th ed. - New York: Springer International Publishing, 2016; 165.