Website is intended for physicians



In the article considers modern commercial method of production is demanded used in oncology medical product radiopharmaceutical 18F-fluorodeoxyglucose (2-fluoro,18F-2-deoxy-D-glucose, 18F-FDG), are presented the process steps and operation of synthesis, quality control procedures, briefly described the requirements for packaging and labeling of radiopharmaceutical.




1.     Kam Leung. [18F]Fluoro-2-deoxy-2-D-glucose in Molecular Imaging and Contrast Agent Database (MICAD). National Center for Biotechnology Information, NLM, NIH, Bethesda, MD. 2005.

2.     Min-Fu Yang, Diwakar Jain, Zuo-Xiang He. 18F-FDG Cardiac Studies for Identifying Ischemic Memory. Curr Cardiovasc Imaging Rep. 2012; Dec, 5:383-389.

3.     Ghesani M., Depuey E. G., Rozanski A. Role of F-18 FDG positron emission tomography (PET) in the assessment of myocardial viability. Echocardiography. 2005 Feb; 22(2): 165-77.

4.     Nose H., Otsuka H., Otomi Y et al. Evaluation of normal physiologic left ventricular myocardial 18F-FDG uptake at fasting state. European Congress of Radiology. 2012. Vienna, Austria. URL: viewing/index.php?module=viewing_poster&doi=10.1594 /ecr2012/C-1192 2012.

5.     Dong Soo Lee, Sang Kun Lee, Myung Chul Lee. Functional Neuroimaging in Epilepsy: FDG PET and Ictal SPECT. Korean Med Sci. 2001;16: 689-96.

6.     Teune L. K., Bartels A. L., Leenders K. L. FDG-PET Imaging in Neurodegenerative Brain Diseases // Functional Brain Mapping and the Endeavor to Understand the Working Brain edited by Francesco Signorelli and Domenico Chirchiglia, 2013.

7.     Sanchez-Catasis C. A., Vallez, Garcha D., Le Riverend Morales E., Galvizu Sбnchez R. Traumatic Brain Injury: Nuclear Medicine Neuroimaging .PET and SPECT in Neurology. 2014; 923-946.

8.     Masangkay N., Basu S., Moghbel M. et al. Brain 18F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings. Nucl Med Commun. 2014 Oct; 35 (10): 1038-46.

9.       Statistika zlokachestvennyh novoobrazovanij v Rossii i stranah SNG v 2012 g. Pod redakciej M.I. Davydova, E.M. Aksel'. [Statistics of malignant neoplasms in Russia and CIS countries in 2012. Edited by M.I. Davydova, E.M. Axel.] Moskva, 2014. - 226 s [In Russ].

10.   Jones S. C., Alavi A., Christman D. et al. The radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man. J Nucl Med. 1982; 23, 613-617.

11.   Kuwabara H., Gjedde A. Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate. J Nucl Med. 1991 Apr; 32(4): 692-8.

12.   Data are from International Commission on Radiological Protection. Radiation Dose to Patients from Radiopharmaceuticals. St. Louis, MO. Elsevier; 2000:49. ICRP publication 80.

13.   Ido T., Wan C. N., Fowler J. S. Fluorination with F2: convenient synthesis of 2-deoxy-2-fluoro-d-glucose. J Org Chem. 1977; 42: 2341-2.

14.   Hamacher K., Coenen H. H., Stacklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]- fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986; 27: 235-8.

15.   Toorongian S. A., Mulholland G. K., Jewett D. M. et al. Routine production of 2-deoxy-2-[18F]fluoro-D- glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Int J Rad Appl Instrum B. 1990; 17 (3): 273-9.

16     Normy radiacionnoj bezopasnosti (NRB-99/2009). [Norms of radiation safety (NRB-99/2009).] SP[In Russ].

17.   Osnovnye sanitarnye pravila obespecheniya radiacionnoj bezopasnosti (OSPORB-99/2010). [Basic sanitary rules for ensuring radiation safety (0SP0RB-99/2010)]. SP 2.6.12612-10 [In Russ].

18.   SanPiN «Gigienicheskie trebovaniya po obespecheniyu radiacionnoj bezopasnosti pri podgotovke i provedenii pozitronnoj ehmissionnoj tomografii». [Hygienic requirements for ensuring radiation safety in the preparation and conduct of positron emission tomography.] [ In Russ].

19.   N.A. Gomzina, D.A. Vasil’ev, R.N. Krasikova. Optimization of Automated Synthesis of 2-[18F]Fluoro- 2-deoxy-D-glucose Involving Base Hydrolysis. Radiochemistry. 2002; 44 (4): 403-409.

20.   Gopal B. Saha. Basics of PET Imaging: Physics, Chemistry and Regulations. - 3th ed. - New York: Springer International Publishing, 2016; 165. (АНГИОЛОГИЯ.ру) - портал о диагностике и лечении заболеваний сосудистой системы