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Abstract:

Purpose: South Kazakhstan Regional Cancer Clinic presents the immediate results of hepatic artery chemotherapy infusion and chemoembolization in patients with hepatic tumors. 

Material and methods: hepatic artery chemoembolization and chemotherapy infusion was performed in 70 patients (47 males, 67,1%) with hepatic tumors since 2004-2008. There were all in all 42 cases (60%) of primary hepatic carcinoma, and in 28 patients (40%) the procedure was done for liver metastatic malignancies. Hepatic artery chemotherapy infusion (HACI) was performed in 50 cases, including 32 patients (45,7%) with primary hepatic carcinoma, and 18 patients (25,7%) with metastatic foci. Hepatic artery chemoembolization (HACE) performed in 20 patients, including 10 patients (17,1%) with primary hepatic carcinoma, and 8 cases (11,4%) of metastatic malignancies. 

Results: significant regression of primary cancer foci and uneventful 3 years follow-up were seen in 2 patients (4,76%), partial regression of the lesion - in 6 (14,3%) of cases, tumor stabilization - in 16 (38%), and tumor progression were found in 8 (19%) of patients. 12 months survival with tumor stabilization was 33,3% (14 patients), 18 months survival - 7,14% (3 patients). Post-procedure mortality in terms of 4 to 8 months made up as high as 30,9% (13 patients). HACE procedure resulted with tumor regression in 8 of 10 patients; the effect sustained for 3-5 months already. For the present moment, 2nd and 3d HACE session is scheduled for this group of patients.

Conclusions: HACI is shown to be effective in treatment of primary and to improve the quality of life in 45,2% of cases. Thus, wide use of the method could be recommended in such a complicated category of patients. HACE procedure results are also hopeful, tumor stabilization starting after the first session.

 

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