Abstract: Aim. Was to investigate the efficiency of transluminal laser revascularization of brain in treatment of vascular dementia. Materials and methods. We have examined and treated 665 patients aged 29 to 81 (average age 75) suffering from various kinds of atherosclerotic lesions of cerebral vessels accompanied by developed vascular dementia. The research included: CT, MRI, scintigraphy, rheoencephalography, poliprojectional angiography To perform endovascular treatment we selected 639 patients: Group 1 (CDR-1) - 352, Group 2 (CDR-2) - 184, Group 3 (CDR-3) - 103 patients. To conduct revascularization of main intracranial arteries high-energy laser systems were used; for revascularization of distal intracranial branches low-energy laser systems were used. Results. The clinical outcome depended on the severity of dementia and timing of the intervention. A good clinical outcome in Group 1 was obtained in 281 (79.82%) cases, in Group 2 in 81 (44.02%) cases, in Group 3 in 9 (8.73%) cases. A satisfactory clinical outcome in Group 1 was obtained in 53 (15.34%) cases, in Group 2 in 62 (33.70%) cases, in Group 3 in 31 (30.09%) cases. A relatively satisfactory clinical outcome in Group 1 was obtained in 17 (4.83%) cases, in Group 2 in 41 (22.28%) cases, in Group 3 in 63 (61.16%) cases. No negative effects were observed after the interventions. Conclusions. Evaluating the data obtained it can be concluded that the method of transluminal laser revascularization of cerebral blood vessels is an effective one for the treatment of atherosclerotic lesions of the brain accompanied by dementia. Reference 1. Gillum R.F, Kwagyan J, Obisesan Th.O. Ethnic and Geographic Variation in Stroke Mortality Trends. Stroke:. 2011; 42:3294-3296. 2. Frolich A.MJ, Psychogios M.N, Klotz E, Knauth M, Knauth P. Angiographic Reconstructions From Whole-Brain Perfusion CT for the Detection of Large Vessel Occlusion in Acute Stroke. Stroke. 2012; 43:97-102. 3. Жулев Н.М, Пустозерцев В.Г, Жулев С.Н. Цереброваскулярные заболевания. 2002, М. Москва, BINOM. Zhulev N.M., Pustozertsev, V.G., Zhulev, S.N..(2002) Cerebrovascular Diseases. BINOM, Moscow [In Russ]. 4. Roman G.C. Facts, myths, and controversies in vascular dementia. J. Neurol. Sci. 2004; 226: 49-52. 5. Folstein M.F, Folstein S.E, McHugh P.R. «Mini-mental state.» A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975;12(3):189-98. 6. Skoog I. Psychiatric disorders in the elderly. Can. J. Psychiatry. 2011; 56 (7):387-97. 7. Maksimovich I.V. Long-term Results of Brain Transluminal Laser Revascularization In The Treatment of Ischemic Stroke. J. Am Coll. Cardiol. 2010; 56; B49-0. 8. Максимович И.В. Транслюминальная лазерная ангиопластика в лечении ишемических поражений головного мозга. дис. д-ра мед. наук М, 2004. Maksimovich, I.V. Transljuminal laser angioplasty in treatment of ischemic lesions of a brain. M. D. 2004, dissertation, Moscow [In Russ]. 9. Maksimovich I.V. Transluminal Laser Revascularization of Cerebral Blood Vessels in the Treatment of Ischemic Stroke. J. Am. Coll. Cardiol. 2010;56; B48-9. 10. Mahoney F.I, Barthel D.W. Functional Evaluation: The Barthel Index. Md. State Med. J. 1965; 14: 61-65. 11. El Ali A, Doeppner T.R, Hermann D.M. Increased Blood-Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia: Role of Lipid Peroxidation and Calpain-1/2, Matrix Metalloproteinase-2/9, and RhoA Overactivation. Stroke. 2011;42:3238-3244. 12. Roman G.C, Kalaria R.N. Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiol Aging. 2006; 27(12): 1769-85. 13. Roman G.C. Facts, myths, and controversies in vascular dementia. J. Neurol. Sci. 2004; 226: 49-52. 14. Skoog I. Psychiatric disorders in the elderly. Can. J. Psychiatry. 2011; 56 (7):387-97. 15. Silver F.L, Mackey A, Clark W.M, Brooks W, Timaran C.H, Chiu D, Goldstein L.B, Meschia J.F, Ferguson R.D, Moore W.S, Howard G, Brott T.G. Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST). Stroke. 2011; 42 (3): 675-80. 16. Papanagiotou P, Roth C, Walter S, Behnke S, Grunwald I.Q, Viera J, Politi M, K^ner H, Kostopoulos P, Haass A, Fassbender K, Reith W. Carotid artery stenting in acute stroke. J. Am. Coll. Cardiol. 2011; 58 (23):2363-9. 17. Biamino G., The excimer laser: science fiction fantasy or practical tool? J Endovasc Ther. 2004; 11; Suppl. 2 :II207-22. 18. Benedek I., Hintea T. Current developments in interventional treatment of total terminal aortic occlusions-laser, stenting and balloon angioplasty: experience of cardiology clinic of Targu-Mures. Rom J. Intern. Med. 2005; 43 (3-4): 223-32. 19. Ecanow J.S., Schwartz B.T., Park R. Tibial recanalization with excimer laser angioplasty. Semin InterventRadiol. 2007; 24(1):58-62. 20. Amb
