lymph nodes

DOI: https://doi.org/10.25512/DIR.2015.09.3.10

For quoting:
Skuridin V.S., Chernov V.I., Varlamova N.V., Nesterov E.A., Sinilkin I.G., Zelchan R.V. "Study of functional fitness radiopharmaceuticals «nanocolloids,99mTc-Al2o3» for scintigraphic and intraoperative identification of «sentinel» lymph nodes". Journal Diagnostic & interventional radiology. 2015; 9(3); 76-80.

authors:

Skuridin V.S.

Chernov V.I.

Varlamova N.V.

Nesterov E.A.

Sinilkin I.G.

Zelchan R.V.

keywords:

radiopharmaceutical (RPh)

nanocolloids

«sentinel» lymph node (SLN)

scintigraphy

Abstract:

Aim: was to estimate the functionality of the nanokoloid drug labeled with technetium-99m for scintigraphy and intraoperative detection of «sentinel» lymph nodes (SLN) in experimental animals.

Materials and methods: the study was performed in 6 series of experiments, including 5 white male rats line «Wistar» weighing 300-350 g. Injection of radiopharmaceuticals (RPh) at a dose of 18-20 MBq were performed between the first and second fingers of the front paws of rats.

Results: in scintigraphic studies STL noted that RPh «Nanocolloid, 99mTc-Al₂O₃» accumulation reaches a plateau at the node (10.2%) for 2 hour study and its percentage content is stored at this level until 24 h. Intraoperative study, in all cases it was possible to visualize the STL.

Conclusions: results shows functional fitness RPh «Nanocolloids,99mTc-Al₂O₃» for scintigraphy and intraoperative detection of «sentinel» lymph nodes.

References

1. Semiglazov V.F. Novoe napravlenie v sberegatel'nom i organosohranjajushhem hirurgicheskom lechenii zlokachestvennyh opuholej. [A new trend in savings and organ-surgical treatment of malignant tumors]. Medicinskij vestnik 2009; 35 (504): 12-24 [In Russ].

2. Abu-Rustum N.R., Knoury-Collado F., Gemignani M.L. Tehniques of sentinel lymph node identification for early-stage cervical and uterine cancer. Gynecol. Oncol. 2008; 111(2): 44-50.

3. Altgassen C., Hertel H. et al. Multicenter valida- cion study of the sentinentel lymph node concept in cervical cancer: AGO Study Group. J. Clin. Oncol. 2008; 26: 2943-2951.

4. Kuznecov V.V., Lebedev A.I., Morhov K.Ju., Gricaj A.N. Hirurgija invazivnogo raka shejki matki [Surgery is invasive cervical cancer]. Prakticheskaja onkologija. 2002; 3(3): 178-182 [In Russ].

5. Hauspy J., Beiner M., Harley А. Sentinel Lymph Node in early stage cervical cancer. Gynecol. Oncol. 2008; l08 (1): 256-257.

6. Takeda N., Sakuragi N., Takeda M. et al. Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy. Acta Obstet. Gynecol. Scand. 2002; 81: 1144-1151.

7. Seong S.J., Park H., Yang K.M. et al. Detection of sentinel lymph nodes in patients with early stage cervical cancer. J. Korean Med. Sci. 2007; 22 (1): 105-109.

8. Baggish M.S., Karram M.K. Atlas anatomii taza i ginekologicheskoj hirurgii [Atlas of pelvic anatomy and gynecologic surgery]. London: Izd-vo Elsevier Ltd. 2009; 1172 [In Russ].

9. Lawrenz B., Jauckus J., Kupka M.S. et al. Fertility preservation in >1,000 patients: patient’s characteristics, spectrum, efficacy and risks of applied preservation techniques. Arch. Gynecol. Obstet. 2010; 283(3): 651-656.

10. Klinicheskaja onkoginekologija: Rukovodstvo dlja vrachej. (Pod red. V.P Kozachenko) [Clinical cancers: A Guide for Physicians. (Ed. V. Kozachenko)]. M.: Medicina, 2005; 431[In Russ].

11. Abu-Rustum N.R., Neubauer N., Sonoda Y et al. Surgical and pathologic outcomes of fertility-sparing radical abdominal trachelectomy for FIGO stage IB1 cervical cancer. Gynecol. Oncol. 2008; 111(2): 261-264.