Comparative evaluation of endothelialization of stents with permanent and biodegradable coatings at an early stage with help of optical coherence tomography

DOI: https://doi.org/10.25512/DIR.2017.11.4.01

For quoting:
Bazylev V.V., Shmatkov M.G., Morozov Z. A. "Comparative evaluation of endothelialization of stents with permanent and biodegradable coatings at an early stage with help of optical coherence tomography". Journal Diagnostic & interventional radiology. 2017; 11(4); 11-15.

authors:

Bazylev V.V.

Shmatkov M.G.

Morozov Z. A.

keywords:

endothelialization

drug-eluting stents

optical coherence tomography (OCT)

Abstract:

Aim: was to compare endothelialization of stents with permanent and biodegradable coatings at an early stage with help of optical coherence tomography (OCT).

Materials and methods: this study is a prospective, randomized trial that includes a comparative analysis of OCT data in patients after implantation of coronary stents with biodegradable (study group) and permanent coatings (control group). 98 patients were randomized 1:1 into 2 groups. After 3 months, 10 patients from each group - were randomized to conduct OCT.

Results: we analyzed OCT data of 10 studies in the biodegradable group (1,776 struts and 247 sections) and 10 studies in the permanent coating group (1562 struts and 226 sections). There were no differences in proportion of uncovered (8,9% vs. 8,5%, p=0,49) and non-exposed struts (1,6% vs. 1,3%, p=0,2). Thus, 98,4% of struts in study group and 98.7% in control group were endothelialized.

Conclusions: according to OCT data, similar results were obtained in both groups. After 3 months of observation in two groups, the overwhelming number of struts were endothelialized. At the early stage of observation, none of groups, achievement of endpoints was detected.

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