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Abstract: Introduction: treatment of gastric cancer (GC) remains an urgent problem in oncology. One of the unsolved problems in treatment of gastric cancer remains the treatment of patients with liver metastases. With the development of interventional radiology, it became possible to treat gastric cancer patients with liver metastases. Aim: was to improve results of treatment of gastric cancer patients with liver metastases by using of trans-arterial chemoembolization (TACE). Material and methods: we analyzed results of 60 patients for the period 2008-2020, who suffered for metastatic liver disease, previously they received combined treatment for stomach cancer at various times. The average age of patients was 58,1 ± 5,8 years. When planning TACE, all patients had a general condition above 80% according to Karnovsky, according to ECOG 1-2. All TACE patients with liver metastatic foci were treated with Lipiodol 6-8ml + Doxorubicin 25mg/m2. The interval between TACE cycles was 1,5-2 months. Each patient received 5-6 TACE courses. Results: immediate results showed the effectiveness of treatment after 2 courses of TACE in 49 (81,7%) patients: partial regression was noted in 36 (60%) patients, and significant regression of the process was noted in 13 (21,6%) patients, stabilization of the process was noted in 11(18,3%) patients. With dynamic follow-up 37 (61,7%) patients lived 6 months, 24 (40%) patients lived 12 months, 11 (18,3%) patients lived 18 months, 8 (13,3%) patients lived 24 months, only 3 (5,0%) patients lived 36 months. The median survival rate was 15,5 ± 1,2 months. Conclusions: immediate and long-term results of the study, carrying out TACE in patients with metastases of gastric cancer to the liver was effective in 50% of patients. Currently, to improve the survival rate and quality of life of patients with metastases of gastric cancer, the technique of trans-arterial chemoembolization can be considered as an effective, low-toxic method of treatment and it can be the method of choice. References 1. Mastoraki A, Benetou C, Mastoraki S, et al. The role of surgery in the therapeutic approach of gastric cancer liver metastases. Indian J. Gastroenterol. 2016; 35(5): 331-336. https://doi.org/10.1007/s12664-016-0683-7 2. Kaidarova DR. Indicators of the Oncological Service of the Republic of Kazakhstan for 2019 (statistical and analytical materials), Almaty, 2020, -137 [In Russ]. 3. Kaprin AD, Starinskiy VV, Petrova GV. Malignant neoplasms in Russia in 2016 (morbidity and mortality). - M.: FGBU «MNIOI after named P.A. Herzen» of the Ministry of Health of Russia, 2018. - 250 [In Russ]. 4. Zhang K, Chen L. Chinese consensus on the diagnosis and treatment of gastric cancer with liver metastases. Ther Adv Med Oncol. 2020; 12: 1758835920904803. https://doi.org/10.1177/1758835920904803. 5. Granov AM, et al. Interventional radiology in oncology (ways of development and technology) - SPb.: - Foliant. - 2007. - 88-97 [In Russ]. 6. Gantsev ShKh, Arybzhanov DT, Kulakeev OK. A method of chemotherapy for gastric cancer metastases in the liver. Patent of the Russian Federation No. 2364397 dated 20.08.2009. Bul. 23 [In Russ]. 7. Chen H, Gao S, Yang XZ, et al. Comparison of Safety and Efficacy of Different Models of Target Vessel Regional Chemotherapy for Gastric Cancer with Liver Metastases. Chemotherapy. 2016; 61(2): 99-107. https://doi.org/10.1159/000440945 8. Chen H, Zhang J, Cao G, et al. Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of first-line or second-line systemic chemotherapy. Anticancer Drugs. 2016; 27(2): 118-26. https://doi.org/10.1097/CAD.0000000000000290 9. Sawatsubashi T, Nakatsuka H, Nihei K, Takano T. A Case of Metachronous Multiple Liver Metastases of AFP and PIVKA-Producing Gastric Cancer, Responding to Transcatheter Arterial Chemoembolization. Gan To Kagaku Ryoho. 2020; 47(2): 319-321. 10. Liu SF, Lu CR, Cheng HD, et al. Comparison of Therapeutic Efficacy between Gastrectomy with Transarterial Chemoembolization Plus Systemic Chemotherapy and Systemic Chemotherapy Alone in Gastric Cancer with Synchronous Liver Metastasis. Chin Med J. 2015; 128(16): 2194-201. https://doi.org/10.4103/0366-6999.162497 11. Xu H, Min X, Ren Y, et al. Comparative Study of Drug-eluting Beads versus Conventional Transarterial Chemoembolization for Treating Peculiar Anatomical Sites of Gastric Cancer Liver Metastasis. Med Sci Monit. 2020; 26: 922988.
