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Abstract:

Introduction: surgical treatment of an area of accumulation of breast microcalcifications requires the surgeon to choose the optimal method of surgery. For a long time, the gold standard of surgery was the placement of a wire needle under X-ray control and subsequent removal. In our study, we want to demonstrate one of new methods, which is based on the placement of ultrasound marks in the area of accumulation of calcifications at the preoperative stage and further removal under the control of ultrasound device.

Aim: was to make comparative analysis and estimate the effectiveness of preoperative marking with ultrasound-positive (US-positive) marks in patients with non-palpable breast neoplasms.

Material and methods: the study included 165 patients (age 32 - 71 years). Patients were divided into three groups depending on the preoperative marking. The first group: installed ultrasound-positive Gel Mark UltraCor Bard marks in the region of microcalcifications at the outpatient stage.

The second group: marking with a wire needle «DuaLok» Bard immediately before the operation.

The third group: according to results of a repeated preoperative examination, which included: unilateral mammography in two projections with marker, a skin mark was established in the projection of a non-palpable formation.

Results: study showed that when choosing a surgical treatment using ultrasound-positive marks, the risk of detecting tumor cells at edges of the resection decreases, the time of surgery is shortened, and the volume of resection of healthy breast tissue is minimized.

Study proved that marking using ultrasound-positive marks has an advantage over other methods of preoperative marking and can be implemented in medical organizations that are not equipped with x-ray equipment for marking non-palpable breast formations immediately before surgery.

 

References

1.     Kaprin AD, Starinsky VV, Petrova GV. The status of cancer care for the population of Russia in 2018. MNII P.A. Herzen - branch of the Federal State Budgetary Institution Scientific Research Center for Radiology of the Ministry of Health of Russia, 2019: 236 [In Russ].

2.     World Health Organization. World health statistics 2019.

https://www.who.int/gho/publications/world_health_statistics/2019/EN_WHS_2019_Main.pdf?ua=1

3.     Kaprin AD, Starinsky VV, Petrova GV. Malignant neoplasms in Russia in 2018 (morbidity and mortality). - M.: MNII them. P.A. Herzen - branch of the Federal State Budgetary Institution Scientific Research Center for Radiology of the Ministry of Health of Russia, 2019; 250 [In Russ].

4.     Manuylova OO, Pavlova TV, Didenko VV, et al. Guidelines for the use of the BI-RADS system for mammography examination. Moscow. 2017; 23 [In Russ].

5.     American College of Radiology, ACR BI-RADS Atlas 5th Edition, 2013.

6.     Bonfiglio R, Scimeca M, Urbano N, et al. Breast microcalcifications: biological and diagnostic perspectives. Future Oncol. 2018; 14(30): 3097-3099.

7.     Tardioli S, Ballesio L, Gigli S, et al. Wire-guided Localization in Non-palpable Breast Cancer: Results from Monocentric Experience. Anticancer Res. 2016; 36(5): 2423-2427.

 

Abstract

The clinical case that is presented, demonstrates the need to sub-specialize radiologists in the field of mammology for a qualitative examination of the breast and timely diagnosis, including breast cancer. During last 8 years, the patient regularly (once every two years) underwent mammography in general-specialization medical facilities. According to findings of surveys conducted, nodal pathology of the breast was not identified. During the physical examination in the upper inner quadrant of the left mammary gland, a movable mass that was soldered to the skin up to 2.0 cm. When conducting a survey mammography in two standard projections in the lower inner quadrant of the left mammary gland, the nodal formation of the BIRADS 5 category was visualized. In a retrospective analysis of past mammograms, described above, nodal formation was noted on all presented mammographic images, the growth and changes in semiotic signs of the pathological focus were also observed. After additional diagnostic manipulations, a highly differentiated breast cancer with low mitotic activity was verified. 

 

References

1.     Kaprin A.D., Rozhkova N.I. National guidelines. Mammalogy. 2nd ed. M.: GEOTAR-Media. 2016; 496 [In Russ].

2.     Frantsuzova I.S. Analysis of risk factors for breast cancer. Mezhdunarodnyy nauchno-issledovatel'skiy zhurnal. 2019. -3 (81): 68-74 [In Russ].

3.     Chernaya A.V. Comparative analysis of informative value of digital mammography and mammoscintigraphy in breast cancer diagnostics. Dis. kand. med. nauk. SPb. 2018; 112. [In Russ].

4.     Vasil’ev A.Yu., Мanuylova О.О. Stereoscopic mammography. An alternative method for the breast cancer early diagnosis. Radiologiya-praktika. 2017.- 1(61): 6-14 [In Russ].

5.     Pavlova T.V., Vasil'ev A.Yu., Manuylova O.O. Method of сone-beam breast computed tomography (literature review). Radiologiya-praktika. 2019.-1(73): 21-27 [In Russ].

6.     Rozhkova N.I., Burdina I.I., Zapirova S.B., Kaprin A.D., Labazanova P.G., Mazo M.L., Mikushin S.Yu., Prokopenko S.P., Yakobs O.E. Areas of preventive work with the female population against breast cancer. Akademicheskiy zhurnal Zapadnoy Sibiri. 2019. Vol. 15.-2(79): 6-8 [In Russ].

7.     Visscher D.W. Sclerosingadenosis and risk of breast cancer / D. W. Visscher, A. Nassar, A. C. Degnim. Breast Cancer Res Treat. 2014. 144: 205-212.

8.     Pavlova T.V., Vasil'ev A.Yu., Manuylova O.O., Volobueva E.A. The impact of compliance with the rules of mammography laying on the timely diagnosis of breast cancer (the clinical example). Diagnosticheskaya i interventsionnaya radiologiya. 2019. -2 (13): 60-65 [In Russ].

9.     Shumakova T.A., Solntseva I.A., Safronova O.B., Savello V.E., Serebryakova S.V. The practical application of the international classification of Bi-RADS in mammology practice. Rukovodstvo dlya vrachey - SPb NII skoroy pomoshchi im. I.I.  Dzhanelidze. SPb. 2018; 217 [In Russ].

 

Abstract

Aim: was to evaluate possibilities of puncture biopsy under ultrasound guidance of parasternal lymph nodes in patients with breast cancer.

Material and methods: study included 34 patients with breast cancer. Criteria for inclusion in the study were: primary breast cancer with a central or medial tumor localization, and patients under observation after previously undergoing surgical treatment. All patients underwent an ultrasound examination of the breast and regional zones, including the parasternal lymphatic collector. All patients underwent biopsy.

Results: in total, 39 parasternal lymph nodes suspicious on secondary lesion were detected, of which 17 (43,5%) lymph nodes had a specific lesion, 22 (56,5%) lymph nodes showed cystological signs of hyperplasia according to results of cytological examination. Parasternal lymph nodes metastases were detected in 16 (47,1%) of 34 patients included in our study. In all cases of specific lesion, lymph nodes were rounded, there was a violation of differentiation of anatomical structures, the absence of a central echo complex, a violation of differentiation and thickening of the cortical layer. In the group of primary patients, 3 (27,3%) patients with metastases in parasternal lymph nodes had distant metastases, remaining 8 (72,7%) patients, due to the lesion of the parasternal lymphatic collector, the stage of the disease were adjusted upwards (stage IIIA).

Conclusion: fine-needle aspiration biopsy under ultrasound-guidance in case of suspected secondary lesion of parasternal lymph nodes, can be successfully used to obtain morphological material with minimal traumatic impact, without the use of anesthesia, which will more adequately assess the state of parasternal lymph nodes at the preoperative stage, correctly set the stage of the disease and prescribe the appropriate treatment.

  

References

1.       Хоперия В.Г. Тонкоигольная аспирационная пункционная биопсия узлов щитовидной железы: показания, техника, клиническое применение. Украинский научно-практический центр эндокринной хирургии и трансплантации эндокринных органов и тканей МЗ Украины. Номер: 1 (35), 2011 г. С. 57-67.

2.       Федотов Ю.Н., Воробьев С.Л., Черников РА. Тонкоигольная аспирационная биопсия в диагностике заболеваний щитовидной железы. Корреляция между заключением цитолога и гистолога, технические аспекты. Клиническая и экспериментальная тиреоидология. 2009. Т. 5. № 4. С. 28-32.

3.       Бурдюков М.С., Нечипай А.М. Тонкоигольная пункция под контролем эндоскопической ультрасонографии: осложнения и альтернативы. Российский электронный журнал лучевой диагностики. 2013. Т. 3. № 2. С. 26-37.

4.       Марченко М.Г., Трофимов Е.И., Виноградов В.В. Современные методы выявления метастазов рака гортани и гортаноглотки в лимфатические узлы шеи. Российская оториноларингология. 2011. № 1 (50). С. 114-117.

5.       TNM Classification of Malignant Tumours, 7th ed. Sobin L.H., Gospodarowicz M.K., Wittekind Ch., eds. New York: Wiley-Blackwell; 2009.

6.       V. L. Kovalenko, M. F. Musafirov, R. V. Experience of video-assisted thoracoscopic parasternal lymph node dissection in breast cancer. Dal'nevostochnyj medicinskij zhural 2014 g. [In Russ.]

7.       Ujmanov V.A., Nechushkin M.I., Trigolosov A.V.. Petrovskij A.V., Vishnevskaya YA.V., Zajceva A.A. Surgical techniques for morphological assessment of the state of the parasternal lymphatic collector as part of organ-preserving treatment in patients with breast cancer. Vestnik RONTS im. N.N. Blochina RAMN. Tom 23: 3(89), 2012: 29 34. [In Russ.]

8.       McDonald E, Haagensen C.D. In: Diseases of the breast. 2nd ed. Philadelphia: W. B. Saunders; 1971.

9.       Letyagin V.P., Laktionov K.P, Vysockaya I.V., Kotov V.A. Breast cancer. - M., 1996. - 150 s. [In Russ.]

10.     Sinyakov A.G. Videothoracoscopic parasternal lymphadenectomy in the treatment of breast cancer. Mezhdunarodnyj zhurnal prikladnyh i fundamental’nyh issledovanij. №10, 2014. [In Russ.]

  

Abstract:

We present a clinical case, demonstrating the importance of x-ray technician compliance with rules of laying when performing x-ray examination of the mammary glands. According to the plain analog mammography with low quality, with positioning of not of all parts of the breast - the pathology was not revealed. In repeated mammographic study, conducted by all rules and all methodological aspects, in the upper-outer quadrant of the right breast, nodular newgrowth category BI-RADS 4c, highly suspicious on breast cancer was revealed. After the expansion of the diagnostic algorithm by echography and core-biopsy, low-differentiated breast cancer with high mitotic activity was verified.

 

Referenses

1.      Kaprin AD, Starinskiy V V, Petrova G V. Malignant neoplasms in Russia in 2017 (morbidity and mortality). М. 2018; 263 p [In Russ].

2.      Kanaev CV, Novikov SN, Semiglazov VF. Possibilities of early detection of breast cancer tumors using ultrasound and radionuclide diagnostic methods. Voprosy onkologii. 2011; 57(5): 622-626 [In Russ].

3.      Chernaya AV. Comparative analysis of informative value of digital mammography and mammoscintigraphy in breast cancer diagnostics. Dis. kand. med. nauk. SPb.: FGBU «NMITsO im. N. N. Petrova» MZ RF, 2018; 112 p [In Russ].

4.      Zuy VS, Solov'ev VI, Alieva FV., Garmot'ko AA, Nikitonova NV. Diagnostic sectoral resection as a method for verifying breast cancer in the Smolensk region (20102014). Vestnik Smolenskoy gosudarstvennoy meditsinskoyakademii. 2018; 17(2): 148-151 [In Russ].

5.      Rozhkova N I. The priority of women's health in the national program for the development of oncological services. Medicinskijalfavit. 2018; 2(29), (366): 6-9 [In Russ].

6.      Vasil’ev AYu., Мanuylova ОО. Stereoscopic mammography. An alternative method for the breast cancer early diagnosis. Radiologiya-praktika. 2017; 61(1): 6-14 [In Russ].

7.      Pavlova T V, Vasil'ev A Yu, Manuylova O O. Method of Сone-Вeam Breast Computed Tomography (Literature Review). Radiologiya - praktika. 2019;73(1): 21-27 [In Russ].

8.      Shumakova TA, Solntseva IA, Safronova OB, Savello VE, Serebryakova SV. The practical application of the international classification of Bi-RADS in mammology practice. Rukovodstvo dlya vrachey. SPb NII skoroy pomoshchi im. I.I.Dzhanelidze. SPb., 2018; 217 p. [In Russ].

9.      Sadykov S S, Bulanova Yu A, Zakharova E А. Methods of breast cancer detection. Algoritmy, metody i sistemy obrabotkidannykh. 2012;19(1): 168-178 [In Russ].

10.    Myakin'kov V B. World radiological experience. Radiologicheskiy visnik. 2012;44(3): 43-47 [In Russ].

 

Abstract:

Aim: was to optimize technics of ultrasound-guided vacuum-aspiration breast biopsy at 3 and 4A categories of BI-RADS scale and subsequent maintenance of patients.

Materials and methods: vacuum-aspiration breast biopsy was performed on 100 female patients aged 23-66 years. Long acting anesthetics were used for anesthesia. After the biopsy no residual tissue was detected.

Results: in 15% of cases (n=15), complications requiring different treatment tactics were revealed. According to histological studies 97% of tumors were benign. 3 patients were diagnosed with breast cancer classified into BI-RADS category 3. For 24% (n=24) of women, long-term results were obtained in 6 months with no signs of relapse.

Conclusions: ultrasound-guided vacuum-aspiration breast biopsy is an effective technics, that doesn't require complex preparation and doesn't take a long time to conduct. With sufficient training of the operator, it is possible to effectively control the completeness of the removal of mass. Using of long acting anesthetics allows ensuring good acceptability of the procedure and providing comfort to patients.

 

 

References

1.     Papathamelis T, Heim S, Lux MP. et al. Minimally Invasive Breast Fibroadenoma Excision Using an Ultrasound-Guided Vacuum-Assisted Biopsy Device. Geburtshilfe und Frauenheilkunde 2017; (2):176-181.

2.     Lakoma A, Kim ES, Minimally invasive surgical management of benign breast lesions. Gland surgery. 2014; (2):142-8.

3.     ACR BI-RADS Atlas® 5th Edition. www.acr.org

4.     Bennett I. C. The Changing Role of Vacuum-assisted Biopsy of the Breast: A New Prototype of Minimally Invasive Breast Surgery. Clinical breast cancer. 2017; (5): 323-325

5.     Seo J, Kim SM, Jang M, et al. Ultrasound-guided cable-free 13-gauge vacuum-assisted biopsy of non-mass breast lesions. Public Library of Science one. 2017; 12 (6)

6.     Jung I, Min JK, Hee J M, et al. Ultrasonography-guided 14-gauge core biopsy of the breast: results of 7 years of experience. Ultrasonography. 2018; (1):55-62

7.     Hui-ping Huo., Wen-bo Wan., Zhi-li Wang., et al. Percutaneous Removal of Benign Breast Lesions with an Ultrasound-guided Vacuum-assisted System: Influence Factors in the Hematoma Formation. Chinese medical sciences journal. 2016; (1):31-36.

8.     Zhang YJ, Wei L, Li J., et al. Status quo and development trend of breast biopsy technology. Gland surgery. 2013; (1):15-24.

9.     Xiao-Fang He, Feng Y Jia-Huai Wen, et al. High Residual Tumor Rate for Early Breast Cancer Patients Receiving Vacuum-assisted Breast Biopsy. Journal of Cancer. 2017; 3: 490-496.

10.   Liu S, Zou JL, Zhou FL., et al. Efficacy of ultrasound-guided vacuum-assisted Mammotome excision for management of benign breast diseases: analysis of 1267 cases. Journal of Southern Medical University. 2017; (8):1121-1125.

11.   Brennan M.E., Turner R.M., Ciatto S., et al. Ductal Carcinoma in Situ at Core-Needle Biopsy: Meta-Analysis of Underestimation and Predictors of Invasive Breast Cancer. Radiology 2011; (1):119-128.

12.   Safioleas PM, Koulicheri D, Michalopoulos N, et al. The value of stereotactic vacuum assisted breast biopsy in the investigation of microcalcifications. A six-year experience with 853 patients. Journal of Balkan Union of Oncology. 2017; (2): 340-346.

 

Abstract:

Breast cancer is the most frequent malignant disease in women in the Russian Federation. To reduce the mortality from breast cancer, various measures were used, of which mammographic screening proved its effectiveness. In recent decades, the active process of informatization of health care system in the Russian Federation has predetermined the need to introduce various information systems, including in the screening processes. Thus, on the basis of Research Institute of Clinical and Experimental Radiology of the federal state budget institution «National Research Center of Oncology N.N.Blokhin» the Ministry of Health of the Russian Federation it was developed a system SDRR-MS (System Description, Recommendations and Reporting of Mammography Screening), which can be used both in screening and in diagnostic processes. The system focused on educational process and standardization of a routine practice of radiologists and X-ray technicians in the breast examination. The system allows to unite an unlimited number of hospitals, while standardization processes are realized by means of a formalized description protocol, elaborated on the basis of the existing international standard BI-RADS. This article is focused on one of system component, intended for the description of x-ray breast examination. 

  

References 

1.     Klinicheskie rekomendacii AOR po raku molochnoj zhelezy. Klinicheskie rekomendacii Associacii Onkologov Rossii [Recommendations of the AOR for breast cancer. Clinical recommendations of the Association of Oncologists of Russia.]. 2014; 84S [In Russ].

2.    Prikaz Ministerstva zdravoohranenija RF №36an ot 03 fevralja 2015 goda «Ob utverzhdenii porjadka provedenija dispanserizacii opredelennyh grupp vzroslogo naselenija» [Order of the Ministry of Health of the Russian Federation No. 36an of February 3, 2015 «On approval of the procedure for the clinical examination of certain groups of adults».] [In Russ] https://www.rosminzdrav.ru/documents/8542-prikazministerstva-zdravoohraneniya-rossiyskoy-federatsii-ot-3-fevralya- 2015-g-36an-ob-utverzhdenii-poryadkaprovedeniya-dispanserizatsii-opredelennyh-grupp-vzroslogo-naseleniya

3.     Kochergina N.V., Ivankina O.V., Zamogil'naja Ja.A., Bludov A.B. Pervye rezul'taty distancionnogo mammograficheskogo skrininga raka molochnoj zhelezy [First results of remote mammographic screening of breast cancer.]. Rossijskij onkologicheskijzhurnal. 2014; 3: 15-18 [In Russ].

4.     Kochergina N.V., Bludov A.B, Shhipahina Ja.A., Ivankina O.V. Novye napravlenija uluchshenija skrininga raka molochnoj zhelezy [New directions for improving of screening for breast cancer.] Vestnik rentgenologii i radiologii. 2016; 97(6): 333-339 [In Russ].

5.     Breast Cancer Surveillance Consortium (DCSC) http://www.bcsc-research.org/data/ptlong6.pdf

6.     Perri N. Evropejskoe rukovodstvo po obespecheniju kachestva pri skrininge i diagnostike raka molochnoj zhelezy [European guidelines for quality assurance in the screening and diagnosis of breast cancer.]. Health & Consumer Protection, Directorate-General. 2010. 4th edition [In Russ].

7.    Sinicyn V.E. Sistema opisanij i obrabotki dannyh issledovanija molochnoj zhelezy [Система описаний и обработки данных исследований груди.]. Mammologicheskij atlas. Izd. Medpraktika-M. 2010; 464S [In Russ].

8.     Metodicheskie rekomendacii k prikazu №154 ot 15 marta 2006 goda «O merah sovershenstvovanija medicinskoj pomoshhi pri zabolevanijah molochnoj zhelezy» [Methodical recommendations to the order number 154 from March 15, 2006 «On measures to improve medical care for breast diseases».] [In Russ].

9.     Koljadina I.V., Poddubnaja I.V., Komov D.V. Skrining raka molochnoj zhelezy:mirovoj opyt i perspektivy [Breast cancer screening: world experience and perspectives.] Rossijskij onkologicheskijzhurnal. 2015; 1:42-46 [In Russ].

10.   Poddubnaja I.V., Koljadina I.V., Kalashnikov N.D., Borisov A.A., Makarova M.V. Populjacinnyj cionnyj «portret» raka molochnoj zhelezy v Rossii: analiz dannyh rossijskogo registra [Population «portrait» of breast cancer in Russia: data analysis of the Russian register.]. Sovremennaja onkologija. 2015; 17(1):25-29 [ In Russ].

 

Abstract:

Aim. Was to evaluate technicalfeasibility and safety of the internalmammary artery redistribution embolization during intra-artena chemotherapy in breast cancer

Materials and methods. Between 2000 and 2010 years 42 patients with inflammatory form of local-spread breast cancer received 48 courses of combined treatment, including systemic and arterial chemotherapy plus radiotherapy In 6 patients, blood flow redistribution n the internal mammary artery was performed to avoid undesirable extra-breast perfusion with possible complications such as neuralgia necrosis of the skin, organ dysfunction. Coil embolization of the internal mammary artery was made distally from branches supplying breast tumor. After that, infusion of chemotherapeutic drug-in-iodized oil was performed

Results. Technicalsuccess rate was 100%.There was no complication of embolization and intra-arterialtherapy During further repeated researches, a giography showed persistent occlusion of the embolized branches and compensatory dilation of tumor-feeding arteries.Survivalrate of patients starts from 2-22 months,with continuation of combined treatment.

Conclusion. Redistribution of blood flow in the internal mammary artery is safe and may be used to avoid complications of ntra-arterial chemotherapy in breast cancer. 

 

References 

1.    Гранов А.М., Давыдов М.И. Интервенционная радиология в онкологии. С.-Пб.: «Фолиант». 2007; 344.

2.    Chuang V.P., Wallace S. Hepatic arterial redistribution for intraarterial infusion of hepatic neoplasms. Radiology. 1980; 135 (2): 295-299.

3.    Таразов П.Г., Рыжков В.К. Эмболизация гастродуоденальной артерии при рентгеноэндоваскулярных вмешательствах по поводу цирроза и опухолей печени. Вестник хирургии. 1988; 140 (1): 83-85.

4.    Таразов П.Г., Павловский А.В., Гранов Д.А. Химиоэмболизация при раке головки поджелудочной железы. Вопросы онкологии. 2001; 47 (4): 489-491.

5.    Таразов П.Г. Эмболизация печеночной артерии при нетипичных анатомических вариантах ее строения у больных злокачественными опухолями печени. Вестник рентгенологии. 1990; 2: 28-32.

6.    Salem R., Thurston K.G. Radioembolization with 90 Yttrium microspheresa. Aa state-of-the-art brachytherapy treatment for primary and secondary liver malignancies, technical and methodologic considerations. J. Vasc. Intervent. Radiol. 2006; 17 (8): 1251-1278.

7.    Woods D. et al. Gluteal artery occlusion. Intraarterial chemotherapy of pelvic neoplasms. Radiology. 1985; 155 (2): 341-343.

8.    Корытова Л.И., Гранов А.М., Хазова Т.В. и др. Способ лечения инфильтративно-отечного рака молочной железы. 2177349, Б.И. 2001.

9.    Таразов П.Г., Корытова Л.И., Шачинов Е.Г Внутриартериальная терапия рака молочной железы (обзор литературы). Вопросы онкологии. 2011; 57 (1): 126-131.

10.  Doughty J.C. et al. Anatomical basis of intraarterial chemotherapy for patients with locally advanced breast cancer. Br. J. Surg. 1996; 83 (8): 1128-1130.

11.  McCarter D.H.A. et al. Angiographic embolization of the distal internal mammary artery as an adjunct to regional chemotherapy in inoperable breast carcinoma. J. Vasc. Intervent. Radiol. 1995; 6 (2): 249-251.

 

 

Abstract:

We have performed a comparative analysis of magnetic resonance mammography (MRM) and traditional methods of diagnostics in detection of multifocal and multicentric kinds of breast cancer (BC) growth in 21 patients with difficult anatomy structure of mammary gland (MG) Breast-conserving surgery has been already planned for all these patients

Complex diagnostics included ultrasound(US), X-ray mammography (XRM), MRM with contrast enhancement, diagnostic needle biopsy Minimal size of identified breast tumors on the base of XRM data was 7 mm, ultrasound - 4 mm, at MR mammography - 2 mm XRM and US have detected multifocal tumor growth only in 1 case (5%). MRM revealed multifocal and multicentric tumor growth in 9 (43%) and 4 (19%) patients respectively According to revealed data the volume of surgical treatment has changed: 10 patients (48%) underwent radical resection, 10 (48%) mastectomy and 1 (5%) - partial resection

According to the conducted research it has been revealed that preoperative MR mammography is necessary for treatment planning in patients with breast cancer to avoid cancer recurrence after breast-conserving surgery.  

 

References 

1.    Аксель Е.М. Злокачественные образования молочной железы. Состояние онкологической помощи, заболеваемость и смертность. Маммология. 2006; 1: 9-15.

2.    Аблицова Н.В., Пак Д.Д., Сарибекян Э.К. Возможность выполнения органосохраняющих и реконструктивно-пластических операций при мультицентрическом раке молочной железы. Материалы II Всероссийской научно-практической конференции с международным участием «Научно-организационные аспекты и современные лечебно-диагностические технологии в маммологии». М., 2003; 176-177.

3.    Пак Д.Д., Аблицова Н.В. Лечебная тактика при первично-множественном раке молочной железы. Материалы Всероссийской научно-практической конференции с международным участием 3-4 июля 2007 г. «Профилактика и лечение злокачественных новообразований в современных условиях». Барнаул. 2007; 155.

4.    Brennan M.E. et al. MRI screening of the contralateral breast in women with newly diagnosed breast cancer. Systematic review and meta-analysis of incremental cancer detection and impact on surgical management. J. Clin. Oncol. 2009.

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6.    Zhang Y. et al. The role of contrast-enhanced MR mammography for determining candidates for breast conservation surgery. Breast. Cancer. 2002; 9: 231-239.

7.    Холин А.В. Диагностика рака молочной железы. Перспективы. Маммология. 1996; 4: 5-33.

8.    Anastassiades O. et al. Multicentricity in breast cancer. A study of 366 cases. Am. J. Clin. Pathol. 1993; 99: 238-243.

 

9.    Drew P. et al. Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the preoperative detection of multifocal breast cancer. Ann. Surg. Oncol. 1999; 6: 599-603.

 

10.  Fischer U., Kopka L., Grabbe E. Breast carcinoma. Еffect of the preoperative contrast-enhanced MR imaging on the therapeutic approach. Radiology.  1999; 231: 881-888.

11.  Fischer U. et al. Preoperative MR-mammography in diagnosed breast carcinoma. Useful information or useless extravagance [in German]? Rofo Fortschr Geb RontgenstrNeuen Bildgeb Verfahr. 1994; 161: 300-306.

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Abstract:

The article describes main epidemiological, clinical and morphological diagnostic features of a rare form of breast tumor - hamartoma. Current scientific data accompany results of own seven-year research. Diagnostic features (qualitative elastography) of breast hamartoma are described for the first time ever. Authors draw attention to morphological diversity of the breast hamartoma, which leads to complex radiological semiotics. 

 

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authors: 

 

Abstract:

Good response to neoadjuvant chemotherapy is a favorable prognostic factor in patients with breast cancer. Early response evaluation might spare unnecessary chemotherapy in bad responders. Clinically mammography and ultrasound are used to evaluate response to treatment while being bac predictors of early response. MRI is getting wider acceptance but still lacks necessary accuracy to the absence of functional evaluation. Thus novel methods are being evaluated in early response prediction. Diffusion-weighted MRI, MR-spectroscopy, mammoscintigraphy PET as well as diffusion optic tomography are discussed in the review as potential ways to improve early prediction of response in breast cancer patients undergoing neoadjuvant chemotherapy.

 

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Abstract:

Inflammatory breast cancer (BC) is a locally-spread unresectable primary diffuse form of tumor, occurring in 1- 6% of patients with breast cancer, and is one of the most malignant forms of cancer with a poor prognosis and a low survival rate.

The article describes the clinical case of successful experience in the application of repeated chemoembolization and one cycle of radical radiation therapy in patient with metastatic breast cancer (inflammatory form), resistant to conduct systemic chemotherapy (possibility to transfer tumor into operable condition).

Patient underwent three cycles of chemoembolization into right internal thoracic artery, followed by radical radiotherapy The combination of these techniques allowed to reach a complete response to treatment and subsequently perform a radical mastectomy. Postoperative follow-up period is 85 months of remission without specific therapy.

 

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