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Abstract:

In the article considers modern commercial method of production is demanded used in oncology medical product radiopharmaceutical 18F-fluorodeoxyglucose (2-fluoro,18F-2-deoxy-D-glucose, 18F-FDG), are presented the process steps and operation of synthesis, quality control procedures, briefly described the requirements for packaging and labeling of radiopharmaceutical.

 

 

References

1.     Kam Leung. [18F]Fluoro-2-deoxy-2-D-glucose in Molecular Imaging and Contrast Agent Database (MICAD). National Center for Biotechnology Information, NLM, NIH, Bethesda, MD. 2005.

2.     Min-Fu Yang, Diwakar Jain, Zuo-Xiang He. 18F-FDG Cardiac Studies for Identifying Ischemic Memory. Curr Cardiovasc Imaging Rep. 2012; Dec, 5:383-389.

3.     Ghesani M., Depuey E. G., Rozanski A. Role of F-18 FDG positron emission tomography (PET) in the assessment of myocardial viability. Echocardiography. 2005 Feb; 22(2): 165-77.

4.     Nose H., Otsuka H., Otomi Y et al. Evaluation of normal physiologic left ventricular myocardial 18F-FDG uptake at fasting state. European Congress of Radiology. 2012. Vienna, Austria. URL: http://posterng.netkey.at/esr/ viewing/index.php?module=viewing_poster&doi=10.1594 /ecr2012/C-1192 2012.

5.     Dong Soo Lee, Sang Kun Lee, Myung Chul Lee. Functional Neuroimaging in Epilepsy: FDG PET and Ictal SPECT. Korean Med Sci. 2001;16: 689-96.

6.     Teune L. K., Bartels A. L., Leenders K. L. FDG-PET Imaging in Neurodegenerative Brain Diseases // Functional Brain Mapping and the Endeavor to Understand the Working Brain edited by Francesco Signorelli and Domenico Chirchiglia, 2013.

7.     Sanchez-Catasis C. A., Vallez, Garcha D., Le Riverend Morales E., Galvizu Sбnchez R. Traumatic Brain Injury: Nuclear Medicine Neuroimaging .PET and SPECT in Neurology. 2014; 923-946.

8.     Masangkay N., Basu S., Moghbel M. et al. Brain 18F-FDG-PET characteristics in patients with paraneoplastic neurological syndrome and its correlation with clinical and MRI findings. Nucl Med Commun. 2014 Oct; 35 (10): 1038-46.

9.       Statistika zlokachestvennyh novoobrazovanij v Rossii i stranah SNG v 2012 g. Pod redakciej M.I. Davydova, E.M. Aksel'. [Statistics of malignant neoplasms in Russia and CIS countries in 2012. Edited by M.I. Davydova, E.M. Axel.] Moskva, 2014. - 226 s [In Russ].

10.   Jones S. C., Alavi A., Christman D. et al. The radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man. J Nucl Med. 1982; 23, 613-617.

11.   Kuwabara H., Gjedde A. Measurements of glucose phosphorylation with FDG and PET are not reduced by dephosphorylation of FDG-6-phosphate. J Nucl Med. 1991 Apr; 32(4): 692-8.

12.   Data are from International Commission on Radiological Protection. Radiation Dose to Patients from Radiopharmaceuticals. St. Louis, MO. Elsevier; 2000:49. ICRP publication 80.

13.   Ido T., Wan C. N., Fowler J. S. Fluorination with F2: convenient synthesis of 2-deoxy-2-fluoro-d-glucose. J Org Chem. 1977; 42: 2341-2.

14.   Hamacher K., Coenen H. H., Stacklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]- fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986; 27: 235-8.

15.   Toorongian S. A., Mulholland G. K., Jewett D. M. et al. Routine production of 2-deoxy-2-[18F]fluoro-D- glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin. Int J Rad Appl Instrum B. 1990; 17 (3): 273-9.

16     Normy radiacionnoj bezopasnosti (NRB-99/2009). [Norms of radiation safety (NRB-99/2009).] SP 2.6.1.2523-09.[In Russ].

17.   Osnovnye sanitarnye pravila obespecheniya radiacionnoj bezopasnosti (OSPORB-99/2010). [Basic sanitary rules for ensuring radiation safety (0SP0RB-99/2010)]. SP 2.6.12612-10 [In Russ].

18.   SanPiN 2.6.1.3288-15 «Gigienicheskie trebovaniya po obespecheniyu radiacionnoj bezopasnosti pri podgotovke i provedenii pozitronnoj ehmissionnoj tomografii». [Hygienic requirements for ensuring radiation safety in the preparation and conduct of positron emission tomography.] [ In Russ].

19.   N.A. Gomzina, D.A. Vasil’ev, R.N. Krasikova. Optimization of Automated Synthesis of 2-[18F]Fluoro- 2-deoxy-D-glucose Involving Base Hydrolysis. Radiochemistry. 2002; 44 (4): 403-409.

20.   Gopal B. Saha. Basics of PET Imaging: Physics, Chemistry and Regulations. - 3th ed. - New York: Springer International Publishing, 2016; 165.

Abstract:

A standard X-ray is still the most affordable method of evaluation of patients, including those with spinal diseases since 1895 when X-rays were found and were introduced into general practice. In the standard X-ray examination of the spine and all the anatomical structures located at different depths and different distances, projected onto x-ray film or a screen in the form of planar image. In order to neutralize these drawbacks and to improve visualization, various tomographic techniques have been developed. The most modern and promising diagnostic method is a multisection linear imaging (tomosynthesis), in which a single pass X-ray tube is a series of slices. Digital X-ray tomography with multislice linear are used as a rule, in the world, for examination of breast and lungs. The article presents data on the different types of X-ray tomography in evaluation of patients with tuberculous spondylitis.

 

 

 

 

Abstract:

Development of multilayer digital tomosynthesis technology allows you to get a more accurate imaging of internal organs and tissues in comparison with other traditional radiological methods of investigation, and that is achieved by the possibility of layered imaging of selected anatomical region.

Aim: was to analyze possibilities of digital tomosynthesis in the assessment of lung structure in normal anatomy of organs of chest cavity

Materials and methods: study include patients without lesions of the chest cavity, who underwent digital tomosynthesis in frontal and lateral projections.

Results: basing on analyzed data, we identified features of normal radiological anatomy of the chest cavity using a technique of digital tomosynthesis. Schematically clarified lobar and segmental structure of lungs, as well as airways according to layered imaging. Advantages and disadvantages of the method in imaging of lungs and mediastinal structures are shown.

Conclusion: the use of digital tomosynthesis in the evaluation of chest organs allows to determine main anatomical structures of lungs in more detail, through layered imaging and a high spatial resolution.  

 

References

1.     Galea A. et al. Practical applications of digital tomosynthesis of the chest. Clinical radiology. 2014; 69(4): 424-430.

2.     de Koste J. R. S. et al. Digital tomosynthesis (DTS) for verification of target position in early stage lung cancer patients. Medical physics. 2013; 40(9): 091904.

3.     Dobbins III J. T. et al. Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Medical physics. 2008; 35(6): 2554-2557.

4.     Vikgren J. et al. Comparison of Chest Tomosynthesis and Chest Radiography for Detection of Pulmonary Nodules: Human Observer Study of Clinical Cases 1. Radiology. 2008; 249(3): 1034-1041.

5.     Quaia E. et al. Digital tomosynthesis as a problemsolving imaging technique to confirm or exclude potential thoracic lesions based on chest X-ray radiography. Academic radiology. 2013; 20(5): 546-553.

6.     Jung H. N. et al. Digital tomosynthesis of the chest: utility for detection of lung metastasis in patients with colorectal cancer. Clinical radiology. 2012; 67(3): 232-238.

7.     Nikitin M. M. Possibilities of digital tomosynthesis in the diagnosis of various forms of pulmonary tuberculosis. REJR. 2016; 6 (1): 35-47. [In Russ].

8.     F.Kovach F., Zhebek Z. X-ray anatomical basics of lungs’ examinations. Budapest, 1958; 364 p. [In Russ].

9.     Trofimova T. N. ed. Human X-ray anatomy. SPb.: Publishing house SPbMAPO. 2005; 496 p. [In Russ].

10.   Sapin M. R. ed. Human Anatomy. Moscow, M.: Medicine. 2001; 640 p. [In Russ].

11.   Sinelnikov R. D., Sinelnikov Ya. R. Atlas of human anatomy. M.: Medicine. 1996; 344 p. [In Russ].

12.   Kokov L. S., ed. X-ray Atlas of comparative anatomy. M.: Radiology-Press., 2012; 388 p. [In Russ].

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