Website is intended for physicians
Search:
authors: 

 

Abstract:

 

Primary angioplasty in patients with ST elevation myocardial infarction reduces mortality and reinfarction rate. Immediate restoration of myocardial perfusion has a direct impact on one-year mortality Achieving TIMI 3 flow in epicardial arteries does not mean that the myocardial perfusion has normalized. In addition to that, it is vital to evaluate alternative markers such as rapid resolution of the ST-segment elevation and restoration of optimal distal flow, blush grade 2-3. The intracoronary infusion of adenosine, administered prior to the opening of the artery limiting the size of the infarction and decreases the incidence of no-reflow phenomenon. Direct stent implantation without pre dilation significantly minimizes the incidence of adverse effects. The Amicath catheter (IHT-Cordynamic, Spain) that we use in patients with ST elevation myocardial infarction allow us to obtain an effective myocardial reperfusion, in different clinical situations avoiding the displacement of the thrombus, or a distal embolism, and preventing the no-reflow phenomenon.

 

References

1.     Stone G.W., Grines C.L., Cox D., et al. A prospective, randomized trial comparing balloon angioplasty with or without abciximab to primary stenting with or without abciximab in acute myocardial infarction: primary endpoint analysis from the CADILLAC trial. Circulation 2000; 102: II-664 (abstract).

2.     Stone G.W., Peterson M.A., Lansky A.J., et al.. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J. Am. Coll. Cardiol. 2002 Feb. 20;39(4): 591-7.

3.     Napodano M., Pasquetto G., Saccа S., et al. Intracoronary thrombectomy improves myocardial reperfusion in patients undergoing direct angioplasty for acute myocardial infarction. J. Am. Coll. Cardiol. 2003; 42: 1395-1402.

4.     Svilaas T., Vlaar PJ., Iwan C., et al. Thrombus Aspiration during Primary Percutaneous Coronary Intervention. N. Engl. J. Med. 2008; 358:557-567 February 7, 2008 DOI: 10.1056/NEJ Moa 0706416.

5.     Mahaffey K.W., Puma J.A., Barbagelata N.A., et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial. J. Am. Coll. Cardiol. 1999 Nov 15; 34(6): 1711-20.

6.     Marzilli M., Orsini E., Maraccini P., Testa R. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation. 2000; 101: 2154-59.

7.     Loubeyre C., Morice M., Lefe'vre T., et al. A Randomized Comparison of Direct Stenting With Conventional Stent Implantation in Selected Patients With Acute Myocardial Infarction. JACC. 2002:39(1): 15-21.

8.     Gibson C.M., Maehara A., Lansky AJ., et al. Rationale and design of the INFUSE-AMI study: A 2Ч2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. Am. Heart. J. 2011 Mar; 161 (3): 478-486.e 7. doi: 10.1016/j. ahj. 2010.10.006. Epub 2011 Jan 28. 

ANGIOLOGIA.ru (АНГИОЛОГИЯ.ру) - портал о диагностике и лечении заболеваний сосудистой системы