Abstract

Background: hilar cholangiocarcinoma (Klatskin tumor) is a rare and severe hepatobiliary malignancy of proximal bile ducts with dismal prognosis, slow periductal growth, late metastatic spread and is mostly fatal due to local complications. Surgical resection is considered to be the only curative method to the date, but its results aren't satisfactory as the majority of patients (70-80%) aren't suitable surgical candidates due to a large tumor extent in local hilar area. Moreover, local recurrence rate reaches 80% over 7 years. Thus endobiliary loco-regional technologies have been proposed, one of which is a photodynamic therapy (PDT).

Aim: was to provide provide a preclinical rationale of PDT in Klatskin tumor patients: to describe principles and mechanisms of the method and summary experimental studies data; this can prepare the reader for the second part of the review, which is based on the analysis of clinical studies and can give practical orientation.

Material and methods: 63 domestic and foreign literature sources were analyzed.

Conclusion: endobiliary photodynamic therapy showed its safety and efficacy in many experimental studies and can successfully be applied in clinical practice. 

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