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Abstract:

Aim: was to develop a pharmacokinetic model and simulate the kinetics of radiopharmaceuticals in the human body for the functional study of the hepatobiliary system using the dynamic scintigraphy method.

Materials and methods: the paper uses the method of compartmental modeling of drug pharmacokinetics (pharmacokinetic modeling) and results of dynamic scintigraphy of the hepatobiliary system of a patient with choledocholithiasis before and after endoscopic papillosphincterotomy to identify model parameters.

Results: various methods of model parameters identification based on quantitative data of hepatobiliscintigraphy are proposed. Results of pharmacokinetic modeling for dynamic scintigraphy of the hepatobiliary system in cases of non-visualizing gallbladder (four-compartment model) and visualizing gallbladder with stimulation of its emptying (five-compartment model) are presented and analyzed.

Conclusion: results of pharmacokinetic modeling presented in the article (calculated quantitative parameters and time activity curves) are in good agreement with the clinical data of dynamic scintigraphy of the hepatobiliary system in normal and pathological conditions. From the comparative analysis of model time activity curves for different zones of interest, the time of stimulation of gallbladder emptying is justified, which normally should be 35-40 min from the beginning of the study.

 

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