Abstract: Purpose: Was to observe the immediate and long-term results of hybrid operations in multilevel atherosclerotic lesions of aorto-iliac(AIS) and femoral-popliteal segments (FPS). Article describes the method of the hybrid intervention in the aorto-iliac segment Materials and Methods: For the period of 2007-2011 - 40 patients with multilevel lesions of iliac arteries and lower limb arteries underwent hybrid operations. 57.5% of patients had aorto-iliac segment disease, classified as TASC C, and 42,5% - TASC D. Lesions of femoral-popliteal segment was divided in the following order: TASC A - 15,0%, TASC B - 35,0%, TASC C - 42,5% and TASC D - 7,5%. We applied loop endarterectomy with stenting for the correction of the aorto-iliac lesions. For arterial outflow correction we applied surgical operations. Follow-up period has been traced for 3 years. Results: Primary technical success was achieved in 97.5%. Complications of the immediate postoperative period were noted in 15%. Long-term results were traced for 3 years in 70% of patients. Three-year assisted patency of aorto-iliac segment was 89%. All complications have been corrected only by endovascular procedure. Three-year cumulative patency of femoral-popliteal segment was 87%. Conclusions: This technique allows achieving the best results in reducing lower limb ischemia. Simultaneous correction of both - inflow and outflow segments improved long-term results of each of the reconstruction. The method shows its effectiveness in patients with TASC C and TASC D lesions of aorto-iliac segment. Reduction of surgical trauma significantly affects the results in group of high risk patients. References 1. Trede M. Rekonstruktive behandlung peripherer durchblutungs-storungen. Radiology. 1973; 308-309. 2. Савельев B.C., Кошкин В.М. Критическая ишемия нижних конечностей. М.: Медицина. 1997; 8. 3. Черненко В.Ф., Гончаренко А.Г., Шувалов А.Ю. и др. Потеря трудоспособности и динамика инвалидизации больных с поражениями сосудов конечностей. Ангиология и сосудистая хирургия. 2005; 11 (2): 21-27. 4. Затевахин И.И., Цициашвили М.Ш., Шиповский В.Н. и др. Новые перспективы сосудистой хирургии - сочетанные эндоваскулярные и открытые операции в реконструкции артериального русла. Анналы хирургии. 1999; 6: 77-84. 5. Lindbom A. Arteriosclerosis and arterial thrombosis in the lower limb. А roentgenological study. Acta Radiol. Suppl. 1950; 80: 1-80. 6. Strandness D.J., Sumner D. Hemodynamics for surgeons. New York: Grune & Stratton. 1975;278-281. 7. Klein W.M., Buskens E., Moll F.L. Vascular and еndovascular rfLallenges. Edited by Roger M. Greenhalgh. BIBA Publishing. 2004;275-281. 8. Pell J.P., Lee A.J. Impact of angioplasty and arterial reconstructive surgery on the quality of life of claudicants. The Scottish Vascular Audit Group. Scott. Med. J. 1997; 42 (2): 47-48. 9. Кириенко А.И., Кошкин В.М., Богачев В.Ю. Амбулаторная ангиология. М.: Лит-терра. 2007; 199-200. 10. Scintu F. Inflow and outflow disease in aorto-femoral grafting. Ital. J. Surg. Sci. 1986; 16 (2): 139-142. 11. Sumner D.S., Strandness D.E. Aortoiliac reconstruction in patients with combined iliac and superficial femoral arterial occlusion. Surgery. 1978; 84: 348-355. 12. Kikta M.J. et al. Longterm follow-up of patients having infrainguinal bypass performed below stenotic but hemodynamically normal aortoiliac vessels. J. Vasc. Surg. 1987; 5:319-328. 13. Diehl J.T. et al. Complication of abdominal aortic reconstruction. Analysis of perioperative risk factors in 557 patients. Ann. Surg. 1983; 197: 49-56. 14. Cooperman M. et al. Cardiovascular risk factors in patients with peripheral vascular disease. Surg. 1978; 84: 5-8. 15. Покровский А.В. Болезни аорты и ее ветвей. М.: Медицина. 1979; 52. 16. Norgren L. et al. TransAtlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Eur. J. Vasc. Endo-vasc. Surg. 2007; 33 (1): 67.