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Immediate and long-term results of pharmacologically "facilitated" percutaneous coronary inter-ventions (PCI) evaluated in 172 patients with myocardial infarction (MI). Pharmacological reperfusion tried prior to PCA with thrombolytic therapy (TLT, streptokinase or tenecteplase) in 81% of patients, and combination TLT + glycoprotein IIb/IIIa inhibitors (abciximab) in 19%. Average symptom onset to reperfusion time was 197±103 min.

Immediately after PCI 88% patients in both groups presented TIMI - 3 flow (р<0.01 to the initial). Repeated PCI during the hospital stay performed in 4 patients (3 in TLT group, 1 in TLT + abciximab group) with recurrent ischemia or subacute vessel occlusion as a cause of intervention. CABG needed in 2 cases. In-hospital survival rate after 'facilitated' PCI was 98,6 - 100%. 6 months clinical follow-up done in 67% of survivors, 16% of them required admission to hospital (recurrent angina due to restenosis), in 9% patients repeated PCI was performed, 6% underwent coronary bypass grafting. All the repeated procedures were success. Overall 6 months mortality was 5%. This prospective study has shown both immediate and long-term safety and efficiency of "facilitated" coronary interventions in patients with myocardial infarction.




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