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Aim: was to optimize treatment of patients with acute myocardial infarction without significant stenotic lesions of coronary arteries.

Materials and methods: authors present a clinical case of treatment of patient, who was admitted in few hours from onset of myocardial infarction. At first-stage, patient underwent manual vacuum thrombectomy, and it revealed the absence of significant stenotic lesions of coronary arteries. Patient underwent coronary angiography, left ventriculography, optical-coherence tomography of the infarct-dependent artery

Results: in this clinical case the cause of myocardial infarction in patient without significant stenotic coronary lesions was the presence of intramural fibrecalcific plaque without signs of instability

Conclusions: according to authors, in order to reduce the incidence of re-thrombosis of coronary arteries in patients with myocardial infarction without stenotic lesions of coronary arteries, it is recommended to perform optical-coherence tomography to reveal unstable atherosclerotic plaque; in such cases it may be warranted stenting of coronary artery.



1.      Sidel'nikov A.V., Chernysheva I.E., Koledinskij A.G.. Sravnitel'nyj analiz ehffektivnosti primeneniya tromboliticheskih preparatov: poisk prodolzhaetsya [Comparative analysis of efficacy of thrombolytic therapy: further search]. Mezhdunarodnyj zhurnal intervencionnoj kardioangiologii. 2014, 39:48-56 [In Russ].

2.      Chandrasekaran B., Kurbaan A. S. Myocardial infarction with angiographically normal coronary arteries. Journal of Royal Society of Medicine. 2002 Aug; 95(8): 398-400.

3.      Reynolds H. R. Myocardial infarction without obstructive coronary artery disease. Current Opinion in Cardiology. 2012, 27:655-660.

4.      Widimsky P., Stellova B., Groch L. et al. Prevalence of normal coronary angiography in the acute phase of suspected ST-elevation myocardial infarction: Experience from the PRAGUE studies; on behalf of the PRAGUE Study Group Investigators. Can J Cardiol. 2006; 22(13): 1147-1152.

5.      Da Costa A., Isaaz K., Faure E. et al. Clinical characteristics, aetiological factors and long-term prognosis of myocardial infarction with an absolutely normal coronary angiogram; a 3-year follow-up study of 91 patients. Eur Heart J. 2001; 22(16): 1459-1465.

6.      Jamil G., Jamil M., Abbas A. et al. «Lone aspiration thrombectomy» without stenting in young patients with ST elevation myocardial infarction - Am J Cardiovasc Dis. 2013; 3(2):71-78.

7.      Escaned J, Echavarrna-Pinto M, Gorgadze T et al. Safety of lone thrombus aspiration without concomitant coronary stenting in selected patients with acute myocardial infarction. EuroIntervention. 2013;8: 1149-1156.

8.      Talarico G. P., Burzotta F., Trani C. et al. Thrombus Aspiration without Additional Ballooning or Stenting to Treat Selected Patients with ST-Elevation Myocardial Infarction. J Invasive Cardiol. 2010; 22(10): 489-492.

9.      Berger J.S., Elliott L., Gallup D. et al. Sex differences in mortality following acute coronary syndromes. JAMA. 2009; 302(8): 874-882.

10.    Dey S., Flather M.D., Devlin G. et al. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart. 2009; 95(1): 20-26.

11.    Roger V.L., Go A.S., Lloyd-Jones D.M. et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation. 2012; 125:e2-e220.

12.    Glagov S., Weisenberg E., Zarins C. et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987; 316: 1371-1375.

13.    Bentzon J. F., Otsuka F., Virmani R., Falk E. Mechanisms of Plaque Formation and Rupture. Circ Res. 2014; 114: 1852-1866.

14.    Shmatkov M.G., Morozova E.V. Opticheskaya kogerentnaya tomografiya: novye vozmozhnosti vnutrisosudistoj vizualizacii (obzor literatury) [Optical cpherence tomography: new possibilities of intravascular imaging (literature review)]. Diagnosticheskaya i intervencionnaya radiologiya, 2013, 7(4): 89-100 [In Russ] .

15.    Virmani    R., Burke A.P., Farb A., Kolodgie F.D. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006; 47: 13-18.

16.    Dhume A.S., Soundararajan K., Hunter W.J. III, Agrawal D.K. Comparison of vascular smooth muscle cell apoptosis and fibrous cap morphology in symptomatic and asymptomatic carotid artery disease. Ann Vasc Surg 2003; 17:1-8.

17.    Burke A.P, Farb A., Malcom G.T. et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997; 336: 1276-1282.

18.    Lam M. K., Sen H., Tandjung K. et al. Clinical Outcome of Patients With Implantation of Second-Generation Drug-Eluting Stents in the Right Coronary Ostium: Insights From 2-Year Follow-up of the TWENTE Trial/ Catheterization and Cardiovascular Interventions 2015; 85:524-531. (АНГИОЛОГИЯ.ру) - портал о диагностике и лечении заболеваний сосудистой системы