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Abstract:

Aim: was to evaluate the effectiveness of endovascular interventions in patients with critical limb ischemia (CLI) with multilevel extended lesions of lower limb arteries of types C and D according to TASC II.

Materials and methods: a retrospective analysis of results of surgical treatment of patients with critical limb ischemia, who underwent 127 endovascular interventions on arteries of the femoral- popliteal-tibial segment for the period from 2007 to 2020, was carried out. 15 patients had ischemic limb pain at rest (11,8%) and 112 patients had trophic lesions (88,2%). Our study included patients with arterial lesions of type C (18 patients, 14,2%) and type D (109 patients, 85,8%) according to TASC II.

Results: technical success of performed endovascular interventions was 95,3%. Within a 30-day period, 2 patients (1,6%) had myocardial infarction, 3 patients (2,4%) underwent early «high» amputation. Perioperative mortality was 0,8% (1 patient). Primary patency of endovascular interventions was 87%, 58% and 36% after 1, 3 and 5 years, respectively, while secondary patency was 91%, 81% and 58% after 1, 3 and 5 years, respectively. Limb salvage rate was 93%, 89% and 79% after 1, 3 and 5 years, respectively. Patient survival rate was 95%, 84% and 78% after 1, 3 and 5 years, respectively.

Conclusions: endovascular interventions on femoral-popliteal-tibial arterial lesions of types C and D according to TASC II in patients with critical limb ischemia are effective, and modern method of treatment with good immediate and long-term results.

 

References

1.     Conte MC, Bradbury AW, Kolh Ph, et al. Global vascular guidelines on the management of chronic limb-threatening ischemia. Journal of Vascular Surgery. 2019; 69(6): 123-125.

https://doi.org/10.1016/j.jvs.2019.02.016

2.     Pokrovskij AV, Ivandeev AS. Sostojanie sosudistoj hirurgii v Rossii v 2016 godu. M.: Obshhestvo angiologov i sosudistyh hirurgov. Moskva. 2017; 76 [In Russ].

3.     Barriocanal АM, L?pez A, Monreal M, Montan? E. Quality assessment of peripheral artery disease clinical guidelines. J Vascular Surgery. 2016; 63(4): 1091-1097.

https://doi.org/10.1016/j.jvs.2015.12.040

4.     Farber A, Eberhardt RT. The Current State of Critical Limb Ischemia. A Systematic Review. JAMA Surg. 2016; 151(11): 1070-1077.

https://doi.org/10.1001/jamasurg.2016.2018

5.     Agarwal S, Sud K, Shishehbor MH. Nationwide trends of hospital admission and outcomes among critical limb ischemia patients: from 2003-2011. J Am Coll Cardiol. 2016; 67(16): 1901-1913.

https://doi.org/10.1016/j.jacc.2016.02.040

6.     Duff S, Mafilio MS, Bhounsul P, Hasegawa JT. The burden of critical limb ischemia: a review of recent literature. Vascular Health and Risk Management. 2019; 15: 187-208.

https://doi.org/10.2147/VHRM.S209241

7.     Darling JD, McCallum JC, Soden PA, et al. Results for primary bypass versus primary angioplasty/stent for lower extremity chronic limb-threatening ischemia. J Vasc Surg. 2017; 66(2): 466-475.

https://doi.org/10.1016/j.jvs.2017.01.024

8.     Antoniou GA, Georgiadis GS, Antoniou SA, et al. Bypass surgery for chronic lower limb ischemia (Review). Cochrane Database of Systematic Reviews. 2017; 3(4): CD002000.

https://doi.org/10.1002/14651858.CD002000.pub3

9.     Uccioli L, Meloni M, Izzo V, et al. Critical limb ischemia: current challenges and future prospects. Vascular Health and Risk Management. 2018; 14: 63-74.

https://doi.org/10.2147/VHRM.S125065

10.   Norgren L, Patel MR, Hiatt WR, et al. Outcomes of Patients with Critical Limb Ischaemia in the EUCLID Trial. Eur J Vasc Endovasc Surg. 2018; 55: 109-117.

https://doi.org/10.1016/j.ejvs.2017.11.006

11.   Spillerov? К, et al. Angiosome Targeted PTA is More Important in Endovascular Revascularisation than in Surgical Revascularisation: Analysis of 545 Patients with Ischaemic Tissue Lesions. Eur J Vasc Endovasc Surg. 2017; 3: 1-9.

https://doi.org/10.1016/j.ejvs.2017.01.008

12.   Pokrovskij AV, Kazakov YuI, Lukin IB. Kriticheskaja ishemija nizhnih konechnostej. Ifraingvinal'noe porazhenie. M.: Tver': Tver. Gos. Un-e. 2018; 225 [In Russ].

13.   Aboyans V, Ricco JB, Bartelink ME, et al. Editor’s choiced 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2018; 55: 305-368.

https://doi.org/10.1093/eurheartj/ehx095

14.   Brouillet J, Deloose K, Goueffic Y, et al. Primary stenting for TASC C and D femoropopliteal lesions: one-year results from a multicentric trial on 203 patients. The Journal of Cardiovascular Surgery. 2018; 59(3): 392-404.

https://doi.org/10.23736/S0021-9509.16.09282-X

15.   Schreuder SM, Hendrix Y, Reekers JA, Bipat S. Predictive Parameters for Clinical Outcome in Patients with Critical Limb Ischemia Who Underwent Percutaneous Transluminal Angioplasty (PTA): A Systematic Review. Cardiovasc Intervent Radiol. 2018; 41(1): 1-20.

https://doi.org/10.1007/s00270-017-1796-9

16.   Norgren L, Patel MR, Hiatt WR, et al. Outcomes of Patients with Critical Limb Ischaemia in the EUCLID Trial. Eur J Vasc Endovasc Surg. 2018; 55: 109-117.

https://doi.org/10.1016/j.ejvs.2017.11.006

17.   Papojan SA, Shhegolev AA, Radchenko AN, et al. Otdalennye rezul'taty jendovaskuljarnogo lechenija porazhenij poverhnostnoj bedrennoj arterii tipov S i D po klassifikacii TASC II. Angiologija i sosudistaja hirurgija. 2018; 24(1): 73-78 [In Russ].

18.   Biagioni RB, Biagioni LC, Nasser F, et al. Infrapopliteal Angioplasty of One or More than One Artery for Critical Limb Ischaemia: A Randomised Clinical Trial. Eur J Vasc Endovasc Surg. 2018; 55: 518-527.

https://doi.org/10.1016/j.ejvs.2017.12.022

19.   Schneider PA, Laird JR, Tepe G, et al. Treatment effect of drug-coated balloons is durable to 3 years in the femoropopliteal arteries: long-term results of the IN.PACT SFA randomized trial. Circ Cardiovasc Interv. 2018; 11 (1): 885-891.

https://doi.org/10.1161/CIRCINTERVENTIONS.117.005891

20.   Reijnen MJ. Outcomes After Drug-Coated Balloon Treatment of Femoropopliteal Lesions in Patients With Critical Limb Ischemia: A Post Hoc Analysis From the IN.PACT Global Study. J Endovasc Ther. 2019; 26: 305-315.

https://doi.org/10.1177/1526602819839044

 

Abstract:

Aim: was to estimate long-term results of vertebral artery (VA) stenting in patients with vertebrobasilar insufficiency (VBI).

Material and methods: study included 194 patients with VBI caused by lesion of V1 segment of VA. All patients received the best course of drug therapy before admission to the clinic. In all these patients, atherosclerotic stenosis of 70% or more of VA was revealed in V1 sergment. All patients underwent surgical correction of V1 segment of VA. Open surgery was performed in «A» group – with a tortuosity of VA – 129(66,5%), in group «B» – without tortuosity of a VA – 65(33,5%) performed stenting of V1 segment of PA.

Bare-metal stents were implanted in 44 patients, drug-eluted stents - 14, renal stents – 7. Distal protection was used in 14 patients. In remaining patients, stenting was performed without embolic protection devices.

Main criteria for evaluating of results were: patency of the reconstruction zone and clinical improvement in the patient after surgery. Statistical processing of results was carried out by calculating ?2, the exact Fisher test (EFT) and constructing of Kaplan-Meier survival curves.

Results: it was determined that in «hopeless» patients, from the point of view of drug treatment, it is possible to achieve a significant clinical effect by surgical methods. Of 194 patients, clinical improvement in the early postoperative period was achieved in 189(97,4%) patients, after 1 year in 177 (91,2%) patients, and after 3 years in 156(80.2%) patients.

In case of stenting of V1 segment of VA – we received excellent immediate results – 100% of technical and clinical success. However, in the long term, results of open operations were better than results of stenting. 3 years after operation, a higher clinical efficacy of open methods was determined – 79,8%, in contrast to stenting – 73,8%. Although, differences were not statistically significant (p> 0,05). 3 years after operation, in case of open operations, a significantly smaller number of restenosis of the reconstruction zone was 1.6%, than with stenting – 15,4% (p <0.05). However, in patients with open operations, more thrombosis of the reconstruction zone were revealed – 5,5% than in patients with stenting – 1.5% (p>0,05). When performing open operations on V1 segment of VA, strokes were fewer – 2.3%, than in group of V1 stenting segment of VA – 3.1% (p> 0.05). When comparing Kaplan-Meyer curves, the median during open surgeries on VA is not achieved after 18 years, and in group of stenting of VA, it occurs after 7 years.

Conclusion: stenting of V1 segment of vertebral arteries in patients with VBI is not the operation of choice in terms of long-term results. However, this operation can be considered as the first stage of brain revascularization in the presence of significant stenosis of V1 segment of vertebral artery and low brain tolerance to ischemia in patients with multiple lesions of brachiocephalic arteries.

 

References

1.     Savitz SI, Caplan LR: Vertebrobasilar disease. N Engl J Med. 2005; 352:2618-2626.

2.     Caplan LR, Wityk RJ, Glass TA, Tapia J, Pazdera L, Chang HM, Teal P, Dashe JF, Chaves CJ, Breen JC, Vemmos K, Amarenco P, Tettenborn B, Leary M, Estol C, Dewitt LD, Pessin MS: New England Medical Center Posterior Circulation registry. Ann Neurol. 2004; 56:389-398.

3.     Vereschagin NV. Pathology of vertebrobasilar system and cerebrovascular accidents. M. 1980; 312. [In Russ].

4.     Puzin MN, Zinoveva GA, МеtelkinaLP. Aspects of medical treatment of patients with vertebrobasilar insufficiency. Klinicheskaya farmakologiya i terapia, 2006; 2: 23-26. [In Russ].

5.     Berguer R, Morasch M, Kline R. A review of 100 consecutive reconstructions of the distal vertebral artery for embolic and hemodynamic disease. J Vasc Surg. 1998; 27 (5): 852-859.

6.     Pokrovskii AV, Belojarcev DF. Long-term results of operations subclavian-carotid transposition. Angiologiya i sosudistaya khirurgiya 2002; 8 (2): 84 - 91. [In Russ].

7.     He Y, Bai W, Li T et al. Perioperative complications of recanalization and stenting for symptomatic nonacute vertebrobasilar arteryocclusion. Ann Vasc Surg. 2014 Feb; 28 (2):386-393.

8.     2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries Endorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS). Eur Heart J. 2018 Mar 1; 39(9): 763-816.

9.     National guidelines on the management of patients with brachiocephalic artery disease. Angiologiya i sosudistaya khirurgiya. 2013; 19 (2), appendix: 70 [In Russ].

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11.   Coward LJ, McCabe DJ, Ederle J, Featherstone RL, Clifton A, Brown MM: Long-term outcome after angioplasty and stenting for symptomatic vertebral artery stenosis compared with medical treatment in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomized trial. Stroke. 2007; 38:1526-1530.

12.   Compter A, van der Worp HB, Schonewille WJ, Vos JA, Algra A, Lo TH, Mali WPThM, Moll FL and Kappelle LJ. VAST: Vertebral Artery Stenting Trial. Protocol for a randomized safety and feasibility trial. Trials 2008; 9: 65.

13.   Clifton A, Markus H, Kuker W, Rothwell P.E-050. The Rationale for the Vertebral artery Ischaemia Stenting trial (VIST): NeuroIntervent Surg 2013; 5. Suppl 2 A56.

14.   Compter A et al. VAST investigators. Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial. Lancet Neurol. 2015 Jun; 14(6): 606-614.

15.   VIST (Vertebral artery Ischaemia Stenting Trial) ISRCT N 95212240.

16.   Markus HS, Harshfield EL, Compter A. et al. Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis. Lancet Neurol. 2019 Jul; 18(7): 666-673.

https://doi.org/10.1016/S1474-4422(19)30149-8

17.   Markus HS, Larsson SC, Dennis J et al. Vertebral artery stenting to prevent recurrent stroke in symptomatic vertebral artery stenosis: the VIST RCT. Health Technol Assess. 2019 Aug; 23(41): 1-30.

 

Abstract:

Infra-popliteal lesions rarely were the zone of interest in first years of endovascular era. Nowadays, broad worldwide experience of transluminal interventions and appearance of low-profile instruments allowed broadening of the indications for transluminal repair of the below-the-knee arteries. The method is proved to be safe and effective.

Results of 121 angioplasties in 70 patients with chronic ischemia of the legs (12 years work of a city hospital) are analyzed in the article. The main indication was stenotic and occlusive infrapopliteal lesions excluding the possibilities of bypass surgery. It was shown that the endovascular approach is extremely effective, and in cases of diabetic angiopathy and critical lower extremities ischemia, an endovascular intervention can be not only the way to save a leg, but the only way to save the patient's life.

 

Reference

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3.     Baum S., Pentecost M.J. Infrapopliteal revascularization. Abrams angiography interventional radiology second edition. 2006;348-261.

4.     Dorros G., Jaff M.R., Kelly K.J. et al. The acuteoutcome of tibioperoneal vessel angioplasty in417 cases with claudication and critical limbischemia. Cathet. Cardiovasc. Diagn. 1998; 45: 251-256..

5.     Alfkel H. Long-term results after infrapopliteal/CIRSE. Италия. 2006.Покровский А.В. Состояние сосудистой хирургии в России в 2006 году. М. 2007; 9-13.

6.     Rizzati R., Tartari S.. Infra-popliteal revascu larization in critical limb ischemia: three year experience in endovascular and surgical treatment/CIRSE. Италия. 2006; 191.

7.     Tsetis D., Belli A.M. The role of infrapopliteal angioplasty. Br. J. Radiol. 2004; 77 (924): 1007-1015.

8.     Затевахин И.И., Шиповский В.Н., Золкин В.Н. Баллонная ангиопластика при ишемии нижних конечностей. М.: Медицина. 2004; 231-249.

9.     Siablis D., Karпabatidis D., Katsanos К. Infrapopliteal paclitaxel-eluting stents for critical limb ischemia: six-month clinical and angiographic results/CIRSE. Италия. 2006; 196.

10.   Зеленов М.А., Ерошкин И.А., Коков Л.С. Особенности ангиографической картины у больных с сахарным диабетом с окклюзионно-стенотическим поражением артерий нижних конечностей. Диагностическая и интервенционная радиология: 2007; 1 (2): 22-30.

 

Abstract:

The purpose of the study is to evaluate the immediate and long-term effectiveness of percutaneous transluminal angioplasty (PTA) in patients with diabetes mellitus (DM) and critical lower limbs ischemia (CLLI).

Since November 2004 till February 2008 42 PTA were performed in 40 patients with CLLI; 28 (70%) of them had ischemic ulceration, in 6 patients (15%) there were foot gangrene, and 6 patients suffered of ischemic rest pain. 30 patients (75%) had the insulin-dependent DM, 8 patients (20%) took antihyperglycemic drugs, 2 (5%) kept to antihyperglycemic diet. There were the following comorbidities: CAD - 30 patients (75%); arterial hypertension - 31 (77,5%); cerebrovascular insufficiency - 15 (37,5%); chronic renal failure - 8 (20%), and 3 patients (7,5%) were on chronic hemodialisis.

One patient (1,4%) had iliac localization of the lesion, 38 (51,4%) - femoropopliteal disease, and there were infrapopliteal lesions in 35 (47,3%) patients. There were prevalence of TASC type C and type D lesions (89,2%), and 81,5% of all infrapopliteal lesions were occlusions. Subintimal tracking was used in 31,5% of lesions. Stenting performed in 2 cases. Angiography success rate was 92,7% - 37 patients. Clinical improvement registered in 36 (90%) patients. 12-month follow-up showed absence of critical ischemia in 72,8% of cases. 

 

 

Reference

 

 

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17.   Long-term mortality and its predictors in patients with critical leg ischaemia. The I.C.A.I. Group (Gruppo di Studio dell'Ischemia Cronica Critica degli Arti Inferiori). The Study Group of Criticial Chronic Ischemia of the Lower Exremities. Eur. J. Vasc. Endovasc. Surg. 1997; 14 (2): 91-95.

 

Abstract:

The aim of the study was to define the factors, having influence to results of repeated percutaneous coronary interventions (PCI) such as isolated balloon angioplasty (BA) and BA in combination with rotational atherectomy (RA), used for treatment of stenosis inside stented segments of coronary arteries. 133 patients, submitted to repeated PCI due to development of stenosis in the stented coronary segments, were included in the study. Clinical and angiographic data were registered three times: at time of initial stenting, during repeated PCI and after 18 monthes of follow-up. Repeated PCI were done together with intracoronary ultrasonography. Decrease of neointimal volume and degree of balloon hyperinflation had not any influence on clinical end-points. Cross-luminal area of the vessel was the only significant prognostic facor for success of repeated PCI. Borderline value of the area was 4,7 sq.mm. Combined technique of PCI (BA + RA) had advantages over isolated BA only in those cases, when large cross-sectional lumen area must be achieved. Good clinical results of patients with cross-sectional lumen area >4,7 sq.mm, obtained after repeated PCI, give possoibility not to use additional interventions. If sufficient increase of the vessel lumen area can not be achieved, an active approach to therapy of such patients should be used after PCI.

The only significant beneficial prognostic factor for success of repeated PCA of the stenosed stented coronary segments was area of the vessels's lumen. It did not depend on technique of revascularisation. Such factors, as decrease of neointimal volume and degree of balloon hyperinflation, had not influence on frequency of restenosis and clinical end-points. 

 

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3.     Reimers В., Moussa I., Akiyama T. et al. long term clinical follow-up after successful repeat percutaneous intervention for stent restenosis. J. Am. Coll. Cardiology.1997; 30: 186-192.

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authors: 

 

Abstract:

The article gives account of coronary stenting impact on the dynamics of left ventricle index. The study covered 94 postinfarction patients, including 80 men and 14 women. Among them 52 patients with Q-forming myocardium infarction and 42 with non-Q myocardium infarction were observed. 1 3 patients that suffered Q-forming myocardium infarction didn't show any segment contractility disorders (group 1), while 39 showed contractility disorders (group 2). The analysis revealed that index improvement of the left ventricle is observed in the 1st group in 77% cases after stenting, while the 2nd group shows no improvements. Among the 2nd group of patients the full recovery is observed in 21% cases, the partial recovery - in 46% and 1 3% didn't overcome any dynamics.

The EchoCG study performed on 42 patients revealed that 31 men have no segmental activity disorders (group 3) and 1 1 suffered segmental activity disorder (group 4). Stenting procedure improved the myocardium function in the 3rd group in 65% cases. In the long prospect 1 0 patients of the 4th group fully recovered their myocardium function and only 1 man showed no dynamics in contractility improvement. Taking into consideration what has been said one can be sure that EchoCG proves to be an effective method of valuing the left ventricle function improvement before and after coronary stenting.

 

References

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Abstract:

A multicentered study based on retrospective data covered 2012 patients and aimed at ascertaining the eficiency of various methods of treating patients with coronary restenosis after stenting. The average percent of complications after restenosis was about 20% during the period of study (1 1+4 months). The metaregression data analysis showed the positive correlation between the stage of residual stenosis of the stentet segment and the probability of complications. As the residual stenosis decreased at 1%, the frequency of complications diminished at 0,9%. Another factors under analysis did not show any evident influence, although we have registered a tendency towards better outcomes of the recurring operations as the diameter of the vessel increased. The recurring balloon angioplasty in cases of short restenosis and intracoronar radiation in cases of diffused restenotic lesions have proved to be the most effective operations. The indications for implanting the additional stents must be given very carefully, especially in cases of diabetes.

 

References

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2.     Serruys P.W, de Jaeger P., Kimeneij E, et al. A comparison of balloon-expandable stent implantation with balloon angioplasty in patients with coronary heart disease. N. Engl]. Med. 1994; 331: 489 - 495.

3.     Di Mario C, Marsico E, Adamian M. et al. New recipes for in-stent restenosis: cut, grate, roast, or sandwich the neointima? Heart. 2000; 84: 471 - 475.

4.     Hoffmann R., Mintz G. S. Coronary in-stent restenosis-predictors, treatment and prevention. Eur. Heart J. 2000; 21: 1739- 1749.

5.     Leon M.B., Tierstein P.S., Moses J.W et al. Localized intracoronary gamma-radiation therapy to inhibit the occurrence of restenosis after stenting. N. Egl. J. Med. 2001; 344: 250-256.

6.     Waksman R., White R.L., Chan R.C., et al. Intracoronary gamma-radiation therapy after angioplasty inhibits reccurence in patients with in-stent restenosis. Circulation. 2000; 101: 2165 - 2171.

7.     Sousa J. E., Costa M.A., Abizaid A., et al. Lack of neoitimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation. 2001; 10: 192 - 195.

8.     Kuntz R.E., Gibson СМ., Nobuyoshi M., et al. Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy. J. Am. Coll. Cardiology. 1993; 21: 15 - 25.

 

Abstract:

We present the clinical case of the effective and safe application of the «Filterwire EZ» embolic protection device (Boston Scientific, USA) for prevention of «no-reflow» phenomenon during primary percutaneous coronary angioplasty in a patient with acute myocardial infarction.

During performing of balloon angioplasty of infarct-related segment of the circumflex left coronary artery with the protection of the distal segments of artery by «Filterwire EZ» device the embolic event was observed. After the final stent implantation the thrombus was removed by embolic protection device, size of the thrombus - 3x4 mm. Control coronarography confirmed the TIMI 3 blood flow in the infarct-related coronary artery.

Presence of different types of devices for capturing or removing of thrombotic masses in the arsenal of interventional cardiologist can improve the results of primary percutaneous coronary angioplasty in patients with acute myocardial infarction. 

 

References 

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2.     Jerlih A.D., Gracianskij N.A. i uchastniki registra REKORD. Lechenie bol'nyh s ostrym koronarnym sindromom s pod#emom ST v stacionarah imejuwih i ne imejuwih vozmozhnosti vypolnenija chreskozhnyh koronarnyh vmeshatel'stv (dannye registra «REKORD»). Aterotromboz. 2009; 1: 120-122 [In Russ].

3.     Jerlih A.D., Gracianskij N.A. ot imeni uchastnikov registra REKORD. Registr ostryh koronarnyh sindromov REKORD. Harakteristika bol'nyh i lechenie do vypiski iz stacionara. Kardiologija. 2009; 7: 4-12 [In Russ].

4.     Anderson J.L., Adams C.D., Antman E.M. et al. ACC/AHA 2007 Guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction — executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction). J. Am. Coll. Cardiol. 2007; 50: 652-726.

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9.     Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with STsegment elevation acute myocardial infarction (ASSENT-4 PCI): randomized trial. Lancet. 2006; 367: 569-578.

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Two-stage treatment of complicated forms of chronic occlusions of coronary arteries



DOI: https://doi.org/10.25512/DIR.2015.09.2.07

For quoting:
Chestukhin V.V., Mironkov B.L., Mironkov A.B., Ryadovoy I.G., Inozemtsev A.S., Sakhovskiy S.A., Azoev E.T. "Two-stage treatment of complicated forms of chronic occlusions of coronary arteries". Journal Diagnostic & interventional radiology. 2015; 9(2); 53-59.

Abstract:

Aim: was to assess dynamics of angiographic parameters of coronary artery rehabilitation, spasm throughout, below chronic coronary occlusion (CCO), after recanalization and balloon angioplasty, with survey of 8-10 weeks, basing on dynamics of anatomical and morphological characteristics of the artery with a major idea to optimize conditions for stenting.

Materials and methods: research analyzes results of two-stage treatment of 26 patients with CCO, complicated by a spasm, by which result after a recanalization of occlusion, was a contrasted artery with diameter less than 1 mm.

In these cases angioplasty with balloons with a diameter up to 3 mm doesn’t yield desirable results and diameter of an artery below a place of occlusion averaged 1,5 mm, and the difference of diameters of proximal and distally department averages 1,78 mm that is an adverse factor for stenting as is followed by high level of restenosis and thrombosis.

Results: within 4-8 weeks (on average 68 days) all arteries remained passable with equal contours, without angiographic signs of dissection, which took place right after balloon angioplasty Diameter of an artery increased with 1,5 mm to 2,64 mm; a difference of diameters of proximal and distally departments of an artery at the level of CCO decreased from 1,78 mm to 0,45 mm that was a favorable condition for stenting.

Conclusion: within 4-8 weeks after recanalization under normal pressure and blood flow occurs a readaptation of artery, expressed in a significant increase in the diameter of the artery below the CCO, which contributes to the optimization of stenting.

 

References

1.    Morino Y, Kimura T., Hayashi Y, Muramatsu T., Ochiai M., Noguchi Y, Kato K., Shibata Y, Hiasa Y, Doi O., Yamashita T., Morimoto T., Abe M., Hinohara T., Mitsudo K.; J-CTO Registry Investigators. In-hospital outcomes of contemporary percutaneous coronary intervention in patients with chronic total occlusion insights from the J-CTO Registry (Multicenter CTO Registry in Japan). JACC Cardiovasc Interv. 2010 Feb;3(2): pp. 143-51.

2.    Buller C.E., Dzavik V., Carere R.G., Mancini G.B., Barbeau G., Lazzam C., Anderson T.J., Knudtson M.L., Marquis J.F., Suzuki T., Cohen E.A., Fox R.S., Teo K.K. Primary stenting versus balloon angioplasty in occluded coronary arteries: the Total Occlusion Study of Canada (TOSCA). Circulation. 1999 Jul 20;100(3): pp. 236-242.

3.    Gould K.L. Coronary collateral function assessed by PET. In: « coronary artery stenosis and reversing atherosclerosis», Ed. By Gould KL,2-nd edition, New York, NY: Oxford University Press, 1999; pp. 275-282.

4.    Pixmeo company. Dr. Antoine Rosset, Prof. Osman Ratib and Joris Heuberger ( Geneva, Switzerland ), 2004;

5.    Okabe T., Mintz G.S., Buch A.N., Roy P, Hong YJ., Smith K.A., Torguson R., Gevorkian N., Xue Z., Satler L.F., Kent K.M., Pichard A.D., Weissman N.J., Waksman R. Intravascular ultrasound parameters associated with stent thrombosis after drug-eluting stent deployment. Am. J. Cardiol. 2007 Aug 15;100(4):615-20. Epub 2007 Jun 29.

6.    Costa M.A,, Angiolillo D.J., Tannenbaum M., Driesman M., Chu A., Patterson J., Kuehl W., Battaglia J., Dabbons S., Shamoon F., Flieshman B., Niederman A., Bass T.A.; STLLR Investigators. Impact of stent deployment procedural factors on long-term effectiveness and safety of sirolimus-eluting stents (final results of the multicenter prospective STLLR trial). Am. J. Cardiol. 2008 Jun 15; 101 (12): 1704-11. doi: 10.1016/j.amjcard.2008.02. 053. Epub 2008 Apr 9.

7.    Hong M.K., Mintz G.S., Lee C.W., Park D.W., Choi B.R., Park K.H., Kim YH., Cheong S.S., Song J.K., Kim J.J., Park S.W., Park S.J. Intravascular ultrasound predictors of angiographic restenosis after sirolimus-eluting stent implantation. Eur. Heart J. 2006 Jun;27(11):1305-10.

8.    Werner G.S., Jandt E., Krack A., Schwarz G., Mutschke O., Kuethe F., Ferrari M., Figulla H.R. Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function. Circulation Oct. 2004; 110(14): pp. 1940-1945.

9.    Sakurai R.L., Ako J., Morino Y, Sonoda S., Kaneda G., Terashima M., Hassan A.H., Leon M.B., Moses J.W.. Popma J.J., Bonneau H.N., Yock PG., Fitzgerald PJ., Honda Y. Predictors of edge stenosis following sirolimus-eluting stent deployment (a quantitative intravascular ultrasound analysis from the SIRIUS trial). SIRIUS Trial Investigators. Am. J. Cardiol. 2005 Nov 1;96(9):1251-3. Epub 2005 Sep 6.

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11.  Kathryn Maiellaro, W. Robert Taylor. The role of the adventitia in vascular inflammation. Cardiovascular Research 2007 Sep 1;75(4): pp. 640-8.

 

 

Abstract:

Case report is devoted to atypical recanalization of chronic occlusions of the common iliac artery Today, there are several ways for recanalization of chronic occlusions of arteries of lower limbs. Recanalization is known to be the major point of endovascular procedures. The success of endovascular surgery at recanalization depends mainly on 2 factors. One of the most important factors is the choice of access. Another factor is the choise of recanalization method . In case of rare failures - performing open surgery.

 

Refrrences 

1.    Pokrovsky A.V. and other. Russian consensus. Recommended standards for the evaluation of patients with chronic lower limb ischemia. M. 2001; 16 [In Russ].

2.    Koshkin V.M. Outpatient treatment of atherosclerotic lesions of lower extremities. Angiology and Vascular Surgery. 1999; 1: 106-113 [In Russ].

3.    Saket R.R. et al. Novel intravaskular ultrasound-guided method to create transintimal arterial communications: initial experience in peripheral occlusive disease and aortic dissection. J.Endovasc. Ther. 2004; 11 (3): 274-280.

4.    Troickij A.V., Behtev A.G., Habazov R.I., Beljakov G.A., Lysenko E.R., Kolodiev G.P. Gibridnaja hirurgija pri mnogojetazhnyh ateroskleroticheskih porazhenijah arterij aorto-podvzdoshnogo i bedrenno-podkolennogo segmentov. Diagnosticheskaja i intervencionnaja radiologija. 2012; 6(4): 67-77 [In Russ].

5.    Zatevakhin 1.1., Shipovskiy V.N., Zolkin V.N. Balloon angioplasty for lower limb ischemia. M. 2004; 176-229 [In Russ].

 

 

Abstract:

Purpose: on the basis of long-term results of renal angioplasty and stenting, the authors define the indications for endovascular interventions in patients with renovascular hypertension (RVH).

Materials and methods: since 1992-2008 in Tashkent Medical Academy Vascular Surgery Center were performed 131 endovascular interventions in 119 patients for renal arteries (RA) stenoses of various origins. 97 patients underwent balloon angioplasty (BA) of renal arteries (105 interventions), and stenting was performed in 22 cases (26 stenting procedures). Systolic blood pressure varied from 170 to 300 mm Hg (219,4±23,1 mmHg), with diastolic blood pressure from 170 to 300 mm Hg (118,1±8,9 mm Hg). Average arterial hypertension history was 5,2±3,7 years (6 months - 16 years).

Results: technical success rate was 85,6% for balloon angioplasty, and 100 % for stenting procedures. Immediate hypotensive effect was good to satisfactory. Complication rate was 2,5% (3 patients). Long-term results were assessed in 76 cases of balloon angioplasty (78,4%), and in all patients with renal arteries stenting. The average follow-up was 72±32,5 months (6-144 months) for balloon angioplasty, and 6-24 months for stenting group. In the angioplasty group long-term hypotensive effect lasted in 54(71,1%) of patients, and the restenosis rate was as high as 28,9% (22 cases). In the stenting group, the long-term hypotensive effect was preserved in all the patients, and there were no cases of restenosis.

Conclusions: high rates of technical and clinical success, as well as low rates of restenosis, allow the renal artery stenting procedure to be seen as the method of choice for renovascular hypertension.

 

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Abstract:

Aim: was to evaluate morphological features of lesions in lower limb arteries before percutaneous transluminal angioplasty (PTA) and its arterial complications in patients with critical lower limb ischemia (CLI) combined with diabetes mellitus(DM).

Materials and methods: for the period from September 2010 to June 2013, a prospective single-center study was conducted involving 171 patients with CLI and DM (80(47%) men, mean age 64,1[54-68] years, mean HbA1c 8,3[7,4-9,6]%, mean duration of diabetes 16,5[8-23] years, diabetes type 1/2-18/153) who underwent PTA in 193 lower limbs. Myocardial infarction and brain stroke in anamnesis had 53(31%) and 19(11%) patients, respectively Chronic kidney disease (CKD) 3-4 stages had 40 patients(24%), end-stage renal disease - 16 cases (10%). Diagnosis of CLI was based on recommendation of TASC II. Patency of arteries of lower limbs was evaluated by duplex ultrasound (DU) before PTA and during early follow-up period (30 days). PTA in all patients was considered technically successful in restoring continuous arterial flow to the foot of at least one crural artery without residual stenosis >50%.

Results: stenosis>50% and occlusions of tibial arteries were found in all patients. Peripheral arterial disease 4-6 classes according Graziani L. classification was marked in 180(93%) cases. Extensive tibial arterial calcification was found in 123(64%) cases, in patients with residual stenosis (> 50% remaining diameter) -113 (89%). The mean value of transcutaneous oxygen pressure (tcpO2) before PTA was 14,7(8-25) mmHg, after PTA - 35,2 (31-38) mmHg. After PTA , residual stenosis (>50%) in treated arteries was in 125(79,1%) cases, thrombosis in treated arteries - 9(5,7%), intimal dissection - 18(11,4%), incomplete stent disclosure - 3(1,9%), incomplete capture stent area stenosis - 2(1,3%), dislocation of the stent - 1(0,6%). Repeat PTA in the early follow-up period was performed in 15 patients with clinically significant complications (6%).

Conclusion: CLI in diabetic patients is characterized by having severe morphological lesions of lower limb arteries, infrapopliteal arterial calcification. DU plays important role in evaluation of arterial patency and PTA complications in early follow-up period. The high level of residual stenosis of tibial arteries after PTA is associated with chronic complications of diabetes mellitus, including renal insufficiency Timely reintervention in diabetic patients with clinical significant PTA complications promotes optimal arterial patency and permission of CLI in theese cases. 

 

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11.   Adam D.J., Beard J.D., Cleveland T., Bell J., Bradbury A.W., Forbes J.F. et al.; BASIL Trial Participants. Bypass versus Angioplasty in Severelschaemia of the Leg (BASIL): multicentre, randomised controlled trial. Lancet. 2005; 366:1925-34.

12.   Norgen L., Hiatt W.R., Dormandy J.A., Nehler M.R., Harris K.A., Fowkes FGR. Inter-society Consensus for the Management of Peripheral Arterial Disease (TASC II). J. Vasc. Surg. 2007; 45(Suppl S):S5-67.

13.   Hirsch A.T., Haskal Z.J., Hertzer N.R., Bakal C.W., Creager M.A., Halperin J. et al; American Association for Vascular Surgery/Society for Vascular Surgery;Society for Cardiovascular Angiography and Interventions;Society for Vascular Medicine and Biology; Society for Inerventional Radiology; ACC/AHA TASC Force on Practice Guidelines. ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (lower exteremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA TASC Forc on Practice Guidelines (writing committee to develop guidelines for the management of patients with peripheral arterial disease)-summary of recommendations. Circulation. 2006 113: e463-654,

14.   Dick F., Ricco J.B., Davies A.H.: Chapter VI: Follow-up after Revascularisation. Eur. J. Vasc. Endovasc. Surg. 2011; 42: S75-S90.

15.   Bondarenko O.N., Ajubova N.L., Galstjan G.R., Dedov 1.1. Dooperacionnaja vizualizacija perifericheskih arterij s primeneniem ul'trazvukovogo dupleksnogo skanirovanja u pacientov s saharnym diabetom i kriticheskoj ishemiej nizhnih konechnostej [Preoperative visualization of peripheral arteries with the help of ultrasonic duplex scanning in patients with critical ischemia of lower limbs and diabetes mellitus]. Saharnyj diabet. 2013; 2: 52-61 [In Russ].

16.   Arvela E., Dick F: Surveillance after Distal Revascularization for Critical Limb Ischemia. Scandinavian Journal of Surgery. 2012; 101:119-124. 

17.   Diehm N., Baumgartner I., Jaff M., Do D.D., Minar E., Schmidli J. et al. A call for uniform reporting standards in studies assessing endovascular treatment for chronic ischemia of lower limb arteries. Eur. Heart J. 2007; 28: 798-805.

authors: 

 

Abstract:

 

Primary angioplasty in patients with ST elevation myocardial infarction reduces mortality and reinfarction rate. Immediate restoration of myocardial perfusion has a direct impact on one-year mortality Achieving TIMI 3 flow in epicardial arteries does not mean that the myocardial perfusion has normalized. In addition to that, it is vital to evaluate alternative markers such as rapid resolution of the ST-segment elevation and restoration of optimal distal flow, blush grade 2-3. The intracoronary infusion of adenosine, administered prior to the opening of the artery limiting the size of the infarction and decreases the incidence of no-reflow phenomenon. Direct stent implantation without pre dilation significantly minimizes the incidence of adverse effects. The Amicath catheter (IHT-Cordynamic, Spain) that we use in patients with ST elevation myocardial infarction allow us to obtain an effective myocardial reperfusion, in different clinical situations avoiding the displacement of the thrombus, or a distal embolism, and preventing the no-reflow phenomenon.

 

References

1.     Stone G.W., Grines C.L., Cox D., et al. A prospective, randomized trial comparing balloon angioplasty with or without abciximab to primary stenting with or without abciximab in acute myocardial infarction: primary endpoint analysis from the CADILLAC trial. Circulation 2000; 102: II-664 (abstract).

2.     Stone G.W., Peterson M.A., Lansky A.J., et al.. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J. Am. Coll. Cardiol. 2002 Feb. 20;39(4): 591-7.

3.     Napodano M., Pasquetto G., Saccа S., et al. Intracoronary thrombectomy improves myocardial reperfusion in patients undergoing direct angioplasty for acute myocardial infarction. J. Am. Coll. Cardiol. 2003; 42: 1395-1402.

4.     Svilaas T., Vlaar PJ., Iwan C., et al. Thrombus Aspiration during Primary Percutaneous Coronary Intervention. N. Engl. J. Med. 2008; 358:557-567 February 7, 2008 DOI: 10.1056/NEJ Moa 0706416.

5.     Mahaffey K.W., Puma J.A., Barbagelata N.A., et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial. J. Am. Coll. Cardiol. 1999 Nov 15; 34(6): 1711-20.

6.     Marzilli M., Orsini E., Maraccini P., Testa R. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation. 2000; 101: 2154-59.

7.     Loubeyre C., Morice M., Lefe'vre T., et al. A Randomized Comparison of Direct Stenting With Conventional Stent Implantation in Selected Patients With Acute Myocardial Infarction. JACC. 2002:39(1): 15-21.

8.     Gibson C.M., Maehara A., Lansky AJ., et al. Rationale and design of the INFUSE-AMI study: A 2Ч2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. Am. Heart. J. 2011 Mar; 161 (3): 478-486.e 7. doi: 10.1016/j. ahj. 2010.10.006. Epub 2011 Jan 28. 

 

Abstract:

A literature review is devoted to endovascular treatment of occlusive and stenotic lesions in arteries of femoral-popliteal segment.

Currently, 2-3% of the RF population suffer from atherosclerotic lesions of arteries of lower limbs. In the structure of cardiovascular disease, atherosclerosis of lower limbs has the level about 20%. In 82% the cause of vascular disease is atherosclerosis. In the structure of atherosclerotic arterial disease of lower limbs more often (47% to 65%) occurs defeat of the femoral-popliteal segment particularly in patients older than 60 years; that is confirmed by numerous statistical observations. The aim of the article was to compare results of endovascular treatment of arterial lesions of the femoral-popliteal segment.

This article presents results of a solo balloon angioplasty, balloon angioplasty with drug-eluting balloons, subintimal angioplasty, stenting drug-eluting and bare-metal stents, cryo-plastics,catheter atherectomy, hybrid interventions and compare results of open and endovascular interventions. Data of STAR register, published in 2001, show that the correction of lesions category C, TASC II, using balloon angioplasty is quite possible to count on similar results in category B.

According to Conrad M. et.al, Amato B. et.al and Dey C., despite the high incidence of the primary success of endovascular interventions for femoral-popliteal segment long-term results often look depressing.

Great importance is given to study the possibility of the use of drug-eluting stents, which have proven effectiveness in suppressing the inflammatory response and intimal hyperplasia after stenting of coronary arteries, as evidenced by research SIROCCO, SIROCCO II, STRIDES, Zilver PTX. Thus, the use of drug-eluting stents in the femoral-popliteal segment did not reduce the frequency of restenosis.

THUNDER, FemPac and LEVANT researches indicate that drug-eluting balloons provide some benefits that are absent in other endovascular techniques such as solo balloon angioplasty and stenting.

The final stage of a multicenter randomized trial BASIL, which carried out a comparative analysis of FPB and PTA groups, was reached in 2010. As a result, the preservation of limbs and survival did not differ significantly

Thus, the literature report reveals a clear tendency of domination of endovascular strategies in defeated limb blood-flow recovery Minimally invasive balloon angioplasty and stenting compared with results of bypass operations, reconstructions - is not worse and consider endovascular treatment strategy in the surgical treatment of femoral-popliteal segment to be method of first choice. 

 

References

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2.     Haimovici's vascular surgery. -5th ed., p.139, 534.

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4.     Diagnostika i lechenija bol'nyh s zabolevanijami perifericheskih arterij: rekomendacii Ros. Obshhestva angiologov i sosudistyh hirurgov. [Diagnostics and treatment of patients with peripheral arterial disease: recommendations of Rus. Society of Angiology and Vascular Surgery.] M., 2007; 135 S. [in Russ.]

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6.     Varty K., Nydahl S., Nasim A., Bolia A. et. al. Results of surgery and angioplasty for the treatment of chronic severe lower limb ischaemia. Eur. J. Vasc. Endovasc. Surg. 1998;16:159-163.

7.     Lenti A.F. et al. Endovascular treatment of long lesions of the superficial femoral artery: Results from a multicenter registry of a spiral, covered polytetrafluoroethylene stent. J. Vasc. Surg. 2007;45:32-9.

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9.     Johnston K.W. et al. Femoral and popliteal arteries: Reanalysis of results of balloon angioplasty. Radiology 1992;183:767-771.

10.   Baril M. et al. Outcomes of endovascular interventions for TASC II B and C femoropopliteal lesions. J. Vasc. Surg. 2008; 48: 627-33.

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15.   Amato     B., Iuliano G.P., Markabauoi A.K. et.al. Endovascular proceduras in critical leg ischemia of elderly patients. Acta Biomed Ateneo Parmense. 2005: 76(1): 11-15.

16.   Dey C. Annual congress of the cardiovascular and interventional radiological society of Europe (CIRSE - 2009); Lisbon, Portugal.

17.   Duda S.H., Bosiers M., Lammer J., Scheinert D., Zeller T., Oliva V., Tielbeek A., Anderson J., Wiesinger B. Drug-eluting and bare nitinol stents for the treatment of atherosclerotic lesions in the superficial femoral artery: long-term results from the SIROCCO trial. J. Endovasc. Ther. 2006; 13(6): 701-710.

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28.   Greiner A., Rantner B., Greiner K., Kronenberg F.. Schocke M., Neuhauser B., Bodner J., Fraedrich G., Schlager A. Neuropathic pain after femoropopliteal bypass surgery. J. Vasc. Surg. 2004. Jun; 39(6): 1284-1287.

29.     Forbes J.F., Adam D.J., Bell J., Fowkes F.G., Gillespie I., Raab G.M., Ruckley C.V., Bradbury A.W. Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: Health-related quality of life outcomes, resource utilization, and cost-effectiveness analysis. J. Vasc. Surg. 2010 May; 51(5 Suppl):43S-51S. 

 

Abstract:

Coronary flow limitation during high risk angioplasty in acute coronary syndrome (ACS) patients is an important problem, connecting with inadequate myocardial protection during the coronary intervention.

Aim: was to compare intraoperative cardiohemodynamic in ACS patients during the high risk angioplasty of difficult stenoses in anterior heart arteries with- or without a coronary venous retroperfusion support.

Methods: intervention results of 14 ACS patients were analyzed. In 1st group there were 6 patients (42,9%) with intraoperative myocardial retroperfusion support. In 2nd group - 8 patients (57,1%) without any intraoperative myocardial perfusion support.

Results: during the retroperfusion support in the 1st group , «ST»-segment elevation at 60 sec left main (LM) or left anterior descending artery (LAD) occlusion was significantly lower (ST in V4-V6 - 1,9±1,7 mm) than in patients without retroperfusion (ST in V4-V6 - 3,1±1,7; p = 0,043). In the 2nd group, patients without coronary flow support the «ST»-segment elevation at 60 sec LM or LAD occlusion was significantly higher (ST в V4-V6 - 2,5±0,5; p = 0,043) than at 5 sec LM or LAD occlusion. No significant differences between «ST»-segment and «T»-wave deviation in the beginning and in the end of intervention were in both groups. The same dynamics was demonstrated at the time of blood pressure indexes measurement.

Conclusion: coronary venous retroperfusion is an effective method of coronary flow support during the high risk angioplasty in ACS patients. Retroperfusion technology had no influence on cardiohemodynamic, but reduced the risk of intraoperative adverse cardiac events. 

 

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Abstract:

Article describes results of single-balloon angioplasty and stenting in patients with occlusive-stenotic lesions of femoral-popliteal segment for the period of 30 months. It was performed 209 endovascular interventions, single-balloon angioplasty in 95 patients; stenting - 114 patients. Long-term results of primary patency: 43,1% in group of single-balloon angioplasty 57,1% - in group with stenting.

 

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Abstract:

Aim: was to estimate the importance of restoring blood flow in vertebral arteries in the segment V1 by stenting in patients with multivessel lesions of extracranial arteries and vertebrobasilar insufficiency (VBI).

Material and methods: study include 59 patients with a dominant, long-existing clinic of vertebrobasilar insufficiency, with multivessel lesions of brachiocephalic arteries, lower brain tolerance to ischemia, with the presence of stenosis of segment V1 of vertebral artery more than 70%, which is regarded by neurologists, as the main reason for VBI. All patients should have been undergone carotid revascularization. However, due to multivessel lesions and low perfusion reserve, all patients as the first stage of treatment - underwent stenting of V1 segment of vertebral artery. In 38 patients bare-metal stent were used, in 14 - drug-eluting stents, in 7 - renal stents. Distal protection was used in 12 patients. In remaining patients - stenting was performed without protection.

Results: in immediate postoperative period, technical, angiographic success and clinical improvement were noticed in 100% of patients. All 59 patients underwent the second and subsequent stages of cerebral revascularization without ischemic episodes. The duration of follow-up was from 6 months to 6 years. After 3 months, 55(93,2%) patients sustained clinical improvement, with no restenosis in stents. 4 patients (6,8%) had no clinical improvement: in one patient after 3 months developed ischemic stroke (IS) in vertebrobasilar system(VBS), due to the occlusion of the stent. 1 patients had stent restenosis with the increase of clinical manifestations of VBI, which required additional stenting. After 14 months, 1 patient after stenting had IS in VBS due to stent fractures caused by bone compression.

Conclusion: stenting of V1 segment of vertebral artery in patients with multivessel lesions of brachiocephalic arteries and clinic of VBI, can be considered as the first stage of cerebral revascularization in case of significant stenosis segment V1 vertebral artery and low tolerance to cerebral ischemia.

 

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9.     Natsionalnie rekomendacii po vedeniyu patsientov s zabolevaniyami brakhiotsefal’nikh arteriy. [National guidelines on the management of patients with diseases of brachiocephalic arteries.] Angiologia I sosudistaya khirurgia. 2013; 19 (2): attachment 70.

10.   Schonewille W.J., Algra A., Serena J., Molina C.A., Kappelle L.J. Outcome in patients with basilar artery occlusion treated conventionally. J Neurol Neurosurg Psychiatry. 2005, 76:1238-1241.

11.   Coward L.J., McCabe D.J., Ederle J., Featherstone R.L., Clifton A., Brown M.M. Long-term outcome after angioplasty and stenting for symptomatic vertebral artery stenosis compared with medical treatment in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomized trial. Stroke. 2007, 38: 1526-1530.

12.   Compter A., van der Worp H.B., Schonewille W.J., Vos J.A., Algra .A., Lo T.H., Mali WPThM, Moll FL. and Kappelle L.J. VAST: Vertebral Artery Stenting Trial. Protocol for a randomised safety and feasibility trial. Trials 2008, 9: 65.

13.   Clifton A., Markus H., Kuker W., Rothwell P. E-050. The Rationale for the Vertebral artery Ischaemia Stenting trial (VIST): NeuroIntervent Surg 2013; 5. Suppl 2 A56.

14.   Compter A., et al. VAST investigators. Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial. Lancet Neurol. 2015 Jun; 14(6): 606-614.

15.   VIST (Vertebral artery Ischaemia Stenting Trial) ISRCT N 95212240.

 

 

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