Abstract: The prostate cancer is one of the most widespread forms of malignant new growths at men. Brachytherapy I125 is a modern, hi-tech, effective, rather safe and easily reproduced method of prostate cancer treatment. In the Russian Scientific Center of Roentgenoradiology implantation of microsources I125 in patients with localized and widespread prostate cancer is carried out by since 2003. For the last period 689 implantations of sources I125 were spent. The tumor-specific survival rate after brachytherapy significantly didn't differ from a tumor-specific survival rate after radical prostatectomy. Thus, brachytherapy is a hi-tech, modern method of treatment in patients with prostate cancer and quantity of undesirable postbeam effects is less than after radical prostatectomy. References 1. Каприн А.Д., Подшивалов А.В. Современные аспекты диагностики рака простаты. Андрол. и генит. хирургия. 2002; 1: 39–47. 2. Сивков А.В., Ощепков В.Н., Патаки К.В. Интерстициальная лучевая терапия I125 локализованного рака предстательной железы. Урология. 2004; 1: 21–25. 3. Чиссов В.И., Старинский В.В. Злокачественные новообразования в России в 2008 г. (заболеваемость и смертность). 2010; 256. 4. Stone N.H. et al. Prospective assessment of patient-reported long-term urinary morbidity and associated quality of life changes after I125 rostate brahytherapy. Brachytherapy. 2003; 2 (1): 32–39. 5. De Reijke T.M., Laguna M.P. Department of Urology, Academic Medical Centre, Amsterdam. The Netherlands. Long-term complications of brachy-therapy in local prostate cancer. BJU International. 2003; 92 (8): 869–873.
Abstract: Inflammatory breast cancer (BC) is a locally-spread unresectable primary diffuse form of tumor, occurring in 1- 6% of patients with breast cancer, and is one of the most malignant forms of cancer with a poor prognosis and a low survival rate. The article describes the clinical case of successful experience in the application of repeated chemoembolization and one cycle of radical radiation therapy in patient with metastatic breast cancer (inflammatory form), resistant to conduct systemic chemotherapy (possibility to transfer tumor into operable condition). Patient underwent three cycles of chemoembolization into right internal thoracic artery, followed by radical radiotherapy The combination of these techniques allowed to reach a complete response to treatment and subsequently perform a radical mastectomy. Postoperative follow-up period is 85 months of remission without specific therapy. References 1. Dawood S., Lei X., Dent R. et al. Survival of women inflammatory breast cancer: a lage population-based study. Ann. Oncol. 2014; 25(6): 1143-1151. 2. Wilke D., Colwell B., Dewar R. Inflammatory breast carcinoma: comparison of survival of those diagnosed clinically, pathologically, or with both features. Am Surg. 1998; 64(5):428-431. 3. Henderson M.A., Mc Bride C.M. Secondary inflammatory breast cancer: treatment options. South Med J. 1988; 81(12):1512-15177. 4. Liauw S.L., Benda R.K., Morris C.G, et al, Inflammatory breast carcinoma: Outcomes with trimodality therapy for nonmetastatic disease. Cancer. 200; 100(5): 920-928. 5. Masljukova E.A., Odincova S.V., Korytova L.I., Polikarpov A.A., Zhabina R.M. Vnutriarterial'naja himioterapija i luchevaja terapija v kombinirovannom lechenii bol'nyh rakom molochnoj zhelezy[Intra-arterial chemotherapy and radiation therapy in combined treatment of patients with breast cancer.]. Vestnik novyh medicinskih tehnologij. Jelektronnoe izdanie. 2015:4:2-10 [In Rus]. 6. Belka C. Biological Basis of Combined Radio and Chemotherapy. Multimodal Concepts for Integration of Cytotoxic Drugs. Ed. Brady L.W. et al., Springer, Heidelberg. 2006;3-17. 7. Harada H. Combinations of Antimetabolites and Ionizing Radiation. Multimodal Concepts for Integration of Cytotoxic Drugs. Ed. Brady L.W. et al. Springer, Heidelberg. 2006;19-34. 8. Perez C.A., Fields J.N., Fracasso PM., et. al, Management of locally advanced carcinoma of the breast. Inflammatory carcinoma. Cancer. 1994;74 (Supll 1): 466-76. 9. Chhikvadze T.B. Mesto luchevogo, lekarstvennogo i hirurgicheskogo jetapov v kompleksnom lechenii otechnyh form raka molochnoj zhelezy [Role of beam, medicinal and surgical stages in complex treatment of inflammatory forms of breast cancer]: dis. kand. med. nauk: M., 2008; 82 [In Russ]. 10. Cristofanilli M., Valero V., Buzdar A.U. et al. Inflammatory breast cancer (IBC): patterns of recurrence and micrometastatic homing. Breast Cancer Res. Treat. 2006;100(Suppl 1):155. 11. Fisher B, Brown A, Mamounas E. et. al. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. J Clin Oncol. 1997; 15(7): 2483-2493. 12. Granov A.M., Davydov M.I. Intervencionnaja radiologija v onkologii (puti razvitija i tehnologii) [Interventional radiology in oncology (path of development and technology)]. Izdanie vtoroe, dopolnennoe. Spb: Foliant, 2013;560 [In Russ].
