Abstract:

Background: pulmonary embolism (PE), is one of the most common cardiopulmonary pathologies in the world, has a high risk of developing after major operations on the osteoarticular system. Mortality from PE remains high, ranking third after myocardial infarction and stroke.

Aim: was to identify tomographic signs of PE in patients with osteoarticular pathology in the postoperative period.

Materials and methods: we analyzed results of computed angiopulmonography of 11 patients with suspicion on pulmonary embolism who were operated on osteoarticular pathology at the Federal Center for Traumatology, Orthopedics and Endoprosthetics of the Ministry of Health of the Russian Federation (Cheboksary). Patients showed such indirect signs of PE as discshaped atelectasis of lung tissues, expansion of diameter of pulmonary trunk and right pulmonary artery, signs of congestion in pulmonary circulation and pulmonary hypertension. Direct radiological signs included occlusion of a branch of pulmonary artery by thrombus.

Results: in 91% of examined patients, occlusion of branch of pulmonary artery by thrombus was detected, in 82% of cases - the defeat of branches of right pulmonary artery. Embolism at the level of lobar arteries was detected in 30%, segmental branches - in 60% of patients; signs of pulmonary embolism of one of subsegmental branches of right pulmonary artery - in one patient (10%). Bilateral thrombosis was observed in two patients, including massive bilateral PE in one case. One patient had discoid atelectasis of lung tissues. Expansion of diameter of pulmonary trunk and right pulmonary artery was observed in 78% of patients with PE, signs of congestion in pulmonary circulation - in 27% of cases, pulmonary hypertension - in 73% of cases.

Conclusion: visualization of direct and indirect signs of pulmonary embolism during computed pulmonary angiography confirmed the diagnosis in all examined patients. The detection of blood clots in pulmonary arteries themselves is the main criterion in making the final diagnosis.

References

1.     Nikolaev NS, Trofimov NA, Kachaeva ZA, et al. Prevention and treatment of pulmonary thromboembolism in traumatology and orthopedics. Tutorial. Cheboksary: Publishing house of the Chuvash University, 2020; 108 [In Russ].

2.     Krivosheeva EN, Komarov AL, Shakhnovich RM, et al. Clinical analysis of a patient with antiphospholipid syndrome and submassive pulmonary embolism. Aterotromboz. 2018; (1): 76-87 [In Russ].

https://doi.org/10.21518/2307-1109-2018-1-76-87

3.     Hepburn-Brown M, Darvall J, Hammerschlag G. Acute pulmonary embolism: a concise review of diagnosis and management. Internal Medicine Journal. 2019; 49(1): 15-27.

https://doi.org/10.1111/imj.14145

4.     Ostapenko EN, Novikova NP. Pulmonary embolism: modern approaches to diagnosis and treatment. Ekstrennaya meditsina. 2013; 1(5): 84-110 [In Russ].

5.     Sinyukova AS, Kiseleva LP, Kupaeva VA. A clinical case of recurrent pulmonary embolism and the complexity of the diagnostic search. Sovremennaya meditsina: aktual'nye voprosy. 2015; (42-43): 24-31 [In Russ].

6.     Bagrova IV, Kukharchik GA, Serebryakova VI, et al. Modern approaches to the diagnosis of pulmonary embolism. Flebologiya. 2012; 6(4): 35-42 [In Russ].

7.     Kuznetsov AB, Boyarinov GA. Early diagnosis of pulmonary embolism (review). Sovremennye tekhnologii v meditsine. 2016; 8(4): 330-336 [In Russ].

8.     Bershteyn LL. Pulmonary embolism: clinical manifestations and diagnosis in the light of the new recommendations of the European Society of Cardiology. Kardiologiya. 2015; 55(4): 111-119 [In Russ].

https://doi.org/10.18565/cardio.2015.4.111-119

9.     Sakharyuk AP, Shimko VV, Tarasyuk ES, et al. Pulmonary embolism in clinical practice. Byulleten' fiziologii i patologii dykhaniya. 2015; (55): 48-53 [In Russ].

10.   M Al-hinnawi A-R. Computer-Aided Detection, Pulmonary Embolism, Computerized Tomography Pulmonary Angiography: Current Status. Intech Open. 2019; 19.

http://doi.org/10.5772/intechopen.79339

11.   Gilyarov MYu, Konstantinova EV. How do new approaches to the treatment of pulmonary embolism affect disease outcome? Meditsinskiy sovet. 2017; (7): 48-55 [In Russ].

https://doi.org/10.21518/2079-701X-2017-7-48-55

12.   Konstantinides S. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur. Heart J. 2014; (35): 3033-3080.

13.   Tagalakis V, Patenaude V, Kahn SR, Suissa S. Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort. Am J Med. 2013; 126(832): 13-21.

https://doi.org/10.1016/j.amjmed.2013.02.024

Abstract

Aim: was to determine characteristic signs of instability and threatening rupture of abdominal aortic aneurysms, detected by computed tomography (CT) according to analysis of modern literature.

Materials: international clinical recommendations and studies of 36 domestic and foreign authors on the diagnosis of abdominal aortic aneurysms (AAA) using computed tomography (CT) were studied. We studied publications that describe the pathogenetic mechanisms of AAA rupture, structural changes in the aortic wall and surrounding tissues, which can be regarded as signs of the formation of aneurysm rupture.

Conclusion: according to literature, specific CT signs of aortic wall instability and data on the high diagnostic value of some of them are presented. Methodological aspects of the analysis of CT data are described for large aneurysms and complex configurations.

References

1.      Pokrovskij A.V. (red.). Clinical Angiology: practical guide in in 2 vol. M.: Medicina. 2004. [In Russ]

2.      Davis C.A. Computed tomography for the diagnosis and management of abdominal aortic aneurysms. Surg. Clin. North Am. 2011; 91(1): 185-193.

3.      National guidelines for the management of patients with abdominal aortic aneurysms. Angiologiya i serdechno-sosudistaya hirurgiya. 2013; 19 (2, Pril.): 72. [In Russ]

4.      Prokop M., Galanski M. (red.). Spiral and multilayer computed tomography: in 2 vol. 3-e izd. M.: MEDpress- info. 2011. [ [In Russ]

5.      Pleumeekers H.J., Hoes A.W., van der Does E., et al. Aneurysms of the abdominal aorta in older Aneurysms of the abdominal aorta in older adults. The Rotterdam Study. Am. J. Epidemiol. 1995; 142 (12): 1291-1299.

6.      Singh K., Bonaa K.H., Jacobsen B.K., et al. Prevalence and risk factors for abdominal aortic aneurysms in a ence and risk factors for abdominal aortic aneurysms in a population-based study: the Tromsu Study. Am. J. Epidemiol. 2001; 154 (3): 236-244.

7.      Ahmed M.Z., Ling L., Ettles D.F. Common and uncommon CT findings in rupture and impending rupture of abdominal aortic aneurysms. Clin. Radiol. 2013; 68(9): 962-971.

8.      Genovese E.A., Fonio P, Floridi C. et al. Abdominal vascular emergencies: US and CT assessment. Crit. Ultrasound J. 2013; 5(Suppl 1): S10.

9.      Wadgaonkar A.D., Black J.H. 3rd, Weihe E.K. et al. Abdominal aortic aneurysms revisited: MDCT with multi-planar meconstructions for identifying indicators of instability in the pre- and postoperative patient. Radiographics. 2015; 35 (1): 254-268.

10.    Vorp D. Biomechanics of abdominal aortic aneurysm. J. Biomech. 2007; 40(9): 1887-1902.

11.    Fillinger M.F., Racusin J., Baker R.K. et al. Anatomic characteristics of ruptured abdominal aortic aneurysm on conventional CT scans: Implications for rupture risk. J. Vasc. Surg. 2004; 39 (6): 1243-1252.

12.    Hinchliffe R.J, Alric P, Rose D. et al. Comparison of morphologic features of intact and ruptured aneurysms of infrarenal abdominal aorta. J. Vasc. Surg. 2003; 38(1): 88-92.

13.    Johnson P.T., Fishman E.K. IV contrast selection for MDCT: current thoughts and practice. AJR Am. J. Roentgenol. 2006; 186 (2): 406-415.

14.    Brewster D.C., Cronenwett J.L., Hallett J.W. Jr et al. Guidelines for the treatment of abdominal aortic aneurysms. Report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. J. Vasc. Surg. 2003; 37(5): 1106-1117.

15.    Vu K.N., Kaitoukov Y, Morin-Roy F. et al. Rupture signs on computed tomography, treatment, and outcome of abdominal aortic aneurysms. Insights Imaging. 2014; 5 (3): 281-293.

16.    Halliday K.E., al-Kutoubi A. Draped aorta: CT sign of contained leak of aortic aneurysms. Radiology. 1996; 199(1): 41-43.

17.    Yuksekkaya R., Koner A.E., Celikyay F. et al. Multidetector computed tomography angiography findings of chronic-contained thoracoabdominal aortic aneurysm rupture with severe thoracal vertebral body erosion. Case Rep. Radiol. 2013; 2013: 596517.

18.    Schwartz S.A., Taljanovic M.S., Smyth S. et al. CT findings of rupture, impending rupture, and contained rupture of abdominal aortic aneurysms. AJR Am. J. Roentgenol. 2007; 188 (1): W57-62.

19.    Mehard W.B., Heiken J.P., Sicard G.A. High-attenuating crescent in abdominal aortic aneurysm wall at CT: a sign of acute or impending rupture. Radiology. 1994; 192(2): 359-362.

20.    Radiological diagnosis of diseases of the heart and blood vessels: a national guide. (edited by L.S. Kokova). M.: GEHOTAR-Media. 2011; 256. [ [In Russ]

21.    Erbel R., Aboyans V., Boileau C. et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur. Heart J. 2014; 35 (41): 28732926.

22.    Vorp D.A., Raghavan M.L., Webster M.W. Mechanical wall stress in abdominal aortic aneurysm: Influence of diameter and asymmetry. J. Vasc. Surg. 1998; 27(4): 632639.

23.    Fillinger M.F., Raghavan M.L., Marra S.P. et al. In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk. J. Vasc. Surg. 2002; 36(3): 589-597.

24.    Kontopodis N., Metaxa E., Papaharilaou Y et al. Advancements in identifying biomechanical determinants for abdominal aortic aneurysm rupture. Vascular. 2015; 23(1): 65-77.

25.    Doyle B.J., Callanan A., Burke P.E. et al. Vessel asymmetry as an additional diagnostic tool in the assessment of abdominal aortic aneurysms. J. Vasc. Surg. 2009; 49(2): 443-454.

26.    Giannoglou G., Giannakoulas G., Soulis J. et al. Predicting the risk of rupture of abdominal aortic aneurysms by utilizing various geometrical parameters: Revisiting the diameter criterion. Angiology. 2006; 57(4): 487-494.

27.    Georgakarakos E., Ioannou C.V., Kamarianakis Y et al. The role of geometric parameters in the prediction of abdominal aortic aneurysm wall stress. Eur. J. Vasc. Surg. 2010; 39(1): 42-48.

28.    Moxon J.V., Adam Parr, Emeto T.I. et al. Diagnosis and monitoring of abdominal aortic aneurysm: Current status and future prospects. J. Curr. Probl. Cardiol. 2010; 35: 512-548.

29.    Polzer S., Gasser T.C., Swedenborg J., Bursa J. The impact of intraluminal thrombus failure on the mechanical stress in the wall of abdominal aortic aneurysms. Eur. J. Vasc. Endovasc. Surg. 2011; 41 (4):467-473.

30.    Hunter G.C., LeongS.C., Yu G.S. Aortic blebs: Possible site of aneurysm rupture. J. Vasc. Surg. 1989; 10(1): 93-99.

31.    Rakita D., Newatia A., Hines J.J. et al. Spectrum of CT findings in rupture and impending rupture of abdominal aortic aneurysms. RadioGraphics. 2007; 27(2): 497-507.

32.    Oldenburg W.A., Almerey T. Erosion of lumbar vertebral bodies from a chronic contained rupture of an abdominal aortic pseudoaneurysm. J. Vasc. Surg. Cas. Innovat. Techn. 2016; 2(4): 197-199.

33.    Endovascular aneurysm repair vs. open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomized control trial. Lancet. 2005; 365: 2179-2186.

34.    Zarins C.K., White R.A., Fogarty T.J. Aneurysm rupture after endovascular repair using the aneurx stent graft. J. Vasc. Surg. 2000; 31(5): 960-970.

35.    Zarins C.K., White R.A., Hodgson K.J. et al. Endoleak as a predictor of outcome after endovascular aneurysm repair: AneuRx multicenter clinical trial. J. Vasc. Surg. 2000; 32(1): 90-107.

36.    Bernhard V.M., Mitchell R.S., Matsumura J.S. et al. Ruptured abdominal aortic aneurysm after endovascular repair. J. Vasc. Surg. 2002; 35(6): 1155-1162.

Abstract:

Aim: was to perform a retrospective comparative analysis of clinical and angiographic results of primary endovascular treatment of ischemic stroke in patients who had contraindications for adjuvant thrombolytic therapy, and results of applying standard pharmaco-invasive (thrombolysis and thrombus extraction) treatment.

Material and methods: angiography was performed in 61 patients. The main criterion for the selection of patients for cerebral angiography according to MSCT-angiography, was a confirmed occlusion of a large intracranial vessel (the internal carotid artery or the middle cerebral artery at M1-2 segment). After MSCT-angiography, in the absence of contraindications, (STT) systemic throbolytic therapy (Alteplaza in the standard dose) was started and patients were sent to an endovascular operation, where selective angiography of the syndrome-responsive artery was performed, followed by an endovascular procedure, according to standard procedure. For endovascular treatment, Penumbra Reperfusion catheters - ACE 68 , were used in combination with 3MAX catheters, or stent-retrievers (Trevo, PRESET, ERIC). In a number of cases, the use of retrievers was supplemented with an assisting thrombus aspiration («Solumbra» method). The criterion for the effectiveness of endovascular treatment was the achievement of blood flow in the syndrome-responsible artery TICI 2b - 3. 6 patients with lesion of distal segments of middle cerebral artery (M3-4) or with no occlusion of large intracranial occlusion were excluded from the study.

Results: all 55 patients who received endovascular treatment, retrospectively were divided into two groups depending on the performance of adjuvant STT Group of combined treatment (STT and endovascular procedure (EVP)) included 24 patients; 31 patients were included in the primary EVP group.

Conclusions: basing on results of the study it can be supposed that primary endovascular treatment of ischemic stroke without thrombolysis can provide comparable efficacy and safety of treatment.

References

1.      Bhatia R, Hill MD, Shobha N, Menon B, Bal S, Kochar P Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action. Stroke. 2010; 41:2254-2258.

2.      Coutinho JM, Liebeskind DS, Slater LA, Nogueira RG, Clark W, Dбvalos A. Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemicstroke: a pooled analysis of the SWIFT and STAR studies. JAMA Neurol. 2017;74:268-274.

3.      Broeg-Morvay A, Mordasini P, Bernasconi C, Bьhlmann M, Pult F, Arnold M. Direct mechanical intervention versus combined intravenous and mechanical intervention in large artery anterior circulation stroke: a matched-pairs analysis. Stroke. 2016; 47:1037-1044.

4.      Bellwald S, Weber R, Dobrocky T, Nordmeyer H, et al Direct Mechanical Intervention Versus Bridging Therapy in Stroke Patients Eligible for Intravenous Thrombolysis: A Pooled Analysis of 2 Registries. Stroke. 2017 Nov 7.

5.      Merlino, G., Sponza, M., Petralia, B. et al. Short and long-term outcomes after combined intravenous thrombolysis and mechanical thrombectomy versus direct mechanical thrombectomy: a prospective single-center study. J Thromb Thrombolysis. 2017; 44: 203.

6.      Guedin P, Larcher A, Decroix JP, Labreuche J, Dreyfus JF, Evrard S. Prior IV thrombolysis facilitates mechanical thrombectomy in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2015; 24:952-957.

7.      Behme D, Kabbasch C, Kowoll A, Dorn F, Liebig T, Weber W, Mpotsaris A. Intravenous thrombolysis facilitates successful recanalization with stent-retriever mechanical thrombectomy in middle cerebral artery occlusions. J Stroke Cerebrovasc Dis. 2016; 25:954-959.

8.      Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L. Alteplase reduces downstream microvascular thrombosis and improves the benefit of large artery recanalization in stroke. Stroke. 2015; 46:3241-3248.

9.      Kass-Hout T, Kass-Hout O, Mokin M, Thesier DM, Yashar P, Orion D. Is bridging with intravenous thrombolysis of any benefit in endovascular therapy for acute ischemic stroke? WorldNeurosurg. 2014; 82:e453-458.

Abstract:

Aim. Was to define prognostically meaningful ultrasound criteria for embologenic thrombus.

Materials and methods. 780 patients (800 limbs) with acute venous thrombosis were investigated; first group consisted of 370 patients with pulmonary embolism (PE) confirmed by lungs perfusion scintigraphic study; second group included 410 patients without PE. During ultrasound examination - 545 patients with floating thrombus were detected: 302 patients with PE (1st group) and 243 without PE (2nd group).

Results. In the first group (with PE) floating thrombus were detected in 79,5% of patients, in 20,5% of patients occlusive and nonocclusive thrombus were detected. It turned out that embologenic thrombus were localized more in shin veins (87,5%), popliteal vein (87,5%) and femoral vein (55,7%). Free floating thrombus had a form of elliptic paraboloid (60,1%), irregular form (67,9%), unechogenic structure with unechogenic contour (44,0%) or heterogenic structure with unechogenic contour (33,8%), high mobility (66,5%) (p>0,05). The length of thrombus was the same in both subgroups (p>0,05).

Conclusions. Floating trombus in 55,4% are embologenic, and are often localized in shin veins, popliteal vein and femoral vein. The absence of a floating pieces after PE indicates that occurred fragmentation of thrombus. It is found that embologenic thrombus often have a form of elliptic paraboloid. The length of thrombus can not be used as single criterion for thrombus's embologenic.  

Reference 

1.    Kinney T.B. Update on Inferior Vena Cava Filters. J. Vasc. Intem Radiol. 2003; 14(4) 425-440.

2.    Зубарев А.Р., Богачев В.Ю., Митьков В.В. Ультразвуковая диагностика заболеваний вен нижних конечностей. М.: Видар, 1999;104. Zubarev A.R., Bogachev V.Yu., Mit’kov V.V. Ulytrazvukovaya diagnostika zabolevaniy ven nizhnikh konechnostey [Ultrasound diagnostics of lower limbs’ veins diseases.]. M.: Vidar. 1999; 104 [In Russ].

3.    Харченко В.П., Зубарев А.Р., Котляров П.М. Ультразвуковая флебология. М.: Эники, 2005. 176. Kharchenko V.P., Zubarev A.R., Kotlyarov P.M. Ulytrazvukovaya phlebologia [Ultrasonic phlebology]. M.: Eniki, 2005;176 [In Russ].

4.    Чуриков ДА., Кириенко А.И. Ультразвуковая диагностика болезней вен. М.: Литтерра, 2011; 92. Churikov D.A., Kirienko A.I. Ulytrazvukovaya diagnostika bolezney ven [Ultrasound diagnostics of veins diseases ]. M.: Littera, 2011; 92 [In Russ].

5.    Kirienko A.I., Leontyev S.G., Lebedev I.S. Algoritm vedeniya bolynykh s ostrym venoznym trombosom [Algorythm of treatment tactics in patients with acute vein thrombosis]. Phlebohgiya. 2008; 1:58-62 [In Russ].

6.    Elliott C.G., Goldhaber S.Z., Jensen R.L. Delays in diagnosis of deep vein thrombosis and pulmonary embolism. Chest. 2005;128(5): 3372-3376.

7.    Goodacre S., Sutton A.J., Sampson F.C. Meta-analysis: the value of clinical assessment in the diagnosis of deep venous thrombosis. Ann. Intern. Med. 2005; 143(2): 129-139.

8.    Yablokov E.G., Kirienko A.I., Bogachev V.Yu. Khronicheskaya venoznaya nedostatochnosty [Chronic vein insufficiency]. M.: Bereg.1999; 127 [In Russ].

9.    Savelyev V.S. Phlebologiya. Rukovodstvo dlya vrachey. (Pod redaktsiey) [Phlebology. Medical quide]. M.: Meditsina 2001; 660 [In Russ].

10.  Baldridge E.D., Martin M.A., Welling R.E. Clinical significance of free-floating venous thrombi. J. Vasc. Surg. 1990; 11(1): 62-67.

11.  Norris C.S., Greenfield L.J., Herrmann J.B. Free-floating iliofemoral thrombus. A risk of pulmonary embolism. Arch. Surg. 1985;120(7): 806-808.

12.  Jones T.K., Barnes R.W., Greenfield L.J. Greenfield vena caval filter: rationale and current indications. Ann. Thorac. Surg. 1986; 42(6): 48-55.

13.  Berry R.E., George J.E., Shaver W.A. Free-floating deep venous thrombosis. A retrospective analysis. Ann. Surg. 1990; 211(6): 719-723.

14.  Baud J-M., Stephas L., Ribadeau-Dumas C. et al. Short- and medium-term duplex sonography follow-up of deep venous thrombosis of the lower limbs.J. Clin.Ultrasound. 1998; 26(1):-13.

15.  Anderson D.R., Kovacs M.J, Dennie C. et al. Use of spiral computed tomography contrast angiography and ultrasonography to exclude the diagnosis of pulmonary embolism in the emergency department. J. Emerg. Med. 2005; 29(4): 399-404.

16.  Rossiyskie klinicheskie rekomendatsii po diagnostike, lecheniyu i prophilaktike venoznykh tromboembolicheskikh oslozhneniy [Russian clinical recommendations for diagnostics, treatment and prophylaxis thrombotic complications of veins' diseases]. Phlebologiya. 2010; 1(2): 5-37 [In Russ].